ArticleJournal of the American College of Cardiology2024
Association of Disrupted Delta Wave Activity During Sleep With Long-Term Cardiovascular Disease and Mortality.
Article in Journal of the American College of Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- High prevalence and mortality risk of nocturia in cardiovascular-kidney-metabolic syndrome: a national cohort study and clinical validation.Clinical and experimental nephrology · 2026Article
- Advancements, challenges, and prospects of explainable AI in sleep disordered breathing.Sleep & breathing = Schlaf & Atmung · 2026Review
- SleepJEPA: Learning the latent world of sleep with at-home sleep data to estimate disease risk.medRxiv : the preprint server for health sciences · 2026Article
- Sleep Phenotype, Shift-Related Occupation, and Coronary Plaque Complexity in Young Adults: Association with CT-Derived Functional Ischemia.Global heart · 2026Article
- Sleep disruption from inhalation of biomass smoke: a basis for coincident hypertension?Particle and fibre toxicology · 2025Article
- A textile-based alignment-free electrophysiological sensing sleeve for comprehensive cardiovascular monitoring.Microsystems & nanoengineering · 2025Article
- Sleep Temporal Entropy as a Novel Digital Biomarker of Sleep Fragmentation for Cardiometabolic and Mortality Risk.Research square · 2025Article
- Sleep Duration Irregularity and Risk for Incident Cardiovascular Disease in the UK Biobank.Journal of the American Heart Association · 2025Article
- Role of circadian rhythms in heart failure: insights from myocardial energy metabolism.Journal of translational medicine · 2025Review
- Sleep deficiency exacerbates periodontal inflammation via trigeminal TRPV1 neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sleep Temporal Entropy as a Novel Digital Biomarker of Sleep Fragmentation for Cardiometabolic and Mortality Risk.medRxiv : the preprint server for health sciences · 2025Article
- Impact of Mobile Phone Usage on Sleep Quality Among Medical Students Across Latin America: Multicenter Cross-Sectional Study.Journal of medical Internet research · 2025Article
- The Effect of Sleep Disruption on Cardiometabolic Health.Life (Basel, Switzerland) · 2025Review
- Associations between sleep parameters and falls among older adults with and without cardiovascular disease: Evidence from the China Health and Retirement Longitudinal Study (CHARLS).Geriatrics & gerontology international · 2025Article
- The Role of Sleep in Cardiovascular Disease.Current atherosclerosis reports · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundDelta wave activity is a prominent feature of deep sleep, which is significantly associated with sleep quality.
objectivesThe authors hypothesized that delta wave activity disruption during sleep could predict long-term cardiovascular disease (CVD) and CVD mortality risk.
methodsThe authors used a comprehensive power spectral entropy-based method to assess delta wave activity during sleep based on overnight polysomnograms in 4,058 participants in the SHHS (Sleep Heart Health Study) and 2,193 participants in the MrOS (Osteoporotic Fractures in Men Study) Sleep study.
resultsDuring 11.0 ± 2.8 years of follow-up in SHHS, 729 participants had incident CVD and 192 participants died due to CVD. During 15.5 ± 4.4 years of follow-up in MrOS, 547 participants had incident CVD, and 391 died due to CVD. In multivariable Cox regression models, lower delta wave entropy during sleep was associated with higher risk of coronary heart disease (SHHS: HR: 1.46; 95% CI: 1.02-2.06; P = 0.03; MrOS: HR: 1.79; 95% CI: 1.17-2.73; P < 0.01), CVD (SHHS: HR: 1.60; 95% CI: 1.21-2.11; P < 0.01; MrOS: HR: 1.43; 95% CI: 1.00-2.05; P = 0.05), and CVD mortality (SHHS: HR: 1.94; 95% CI: 1.18-3.18; P < 0.01; MrOS: HR: 1.66; 95% CI: 1.12-2.47; P = 0.01) after adjusting for covariates. The Shapley Additive Explanations method indicates that low delta wave entropy was more predictive of coronary heart disease, CVD, and CVD mortality risks than conventional sleep parameters.
conclusionsThe results suggest that delta wave activity disruption during sleep may be a useful metric to identify those at increased risk for CVD and CVD mortality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.