Evidence map›Paper›PMID 38572959›Full record

ArticleAntimicrobial agents and chemotherapy2024

ABC transporter inhibition by beauvericin partially overcomes drug resistance in

Charbel Al Khoury, Sergio Thoumi, Sima Tokajian, Aia Sinno, Georges Nemer, Mark El Beyrouthy, Kelven Rahy

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Multi-Omics Analysis ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  4. Functional Studies of Kinetoplastid Transporters.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  5. Article
  6. Article
  7. Evaluation of Beauvericin's activity and mode of action against all life stages ofFrontiers in cellular and infection microbiology · 2025
    Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Charbel Al KhouryDepartment of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut, Lebanon.ORCID 0000-0003-0977-1242
Sergio ThoumiDepartment of Computer Science and Mathematics, Lebanese American University, Beirut, Lebanon.
Sima TokajianDepartment of Natural Sciences, School of Arts and Sciences, Lebanese American University, Byblos, Lebanon.
Aia SinnoDepartment of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut, Lebanon.
Georges NemerDivision of Genomics and Translational Biomedicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.
Mark El BeyrouthyDepartment of Agriculture and Food Engineering, Holy Spirit University of Kaslik, Jounieh, Lebanon.
Kelven RahyGilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon.
Lebanese American University · LBHamad bin Khalifa University · QAHoly Spirit University of Kaslik · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leishmaniasis is a neglected tropical disease infecting the world's poorest populations. Miltefosine (ML) remains the primary oral drug against the cutaneous form of leishmaniasis. The ATP-binding cassette (ABC) transporters are key players in the xenobiotic efflux, and their inhibition could enhance the therapeutic index. In this study, the ability of beauvericin (BEA) to overcome ABC transporter-mediated resistance of

Indexed as

Antiprotozoal AgentsATP-Binding Cassette TransportersDepsipeptidesDrug ResistanceLeishmania tropicaMolecular Docking SimulationPhosphorylcholineHumansProtozoan ProteinsAntiprotozoal AgentsATP-Binding Cassette TransportersbeauvericinDepsipeptidesmiltefosinePhosphorylcholineProtozoan ProteinsABC transporterdrug resistanceleishmaniasisLeishmania tropica

Identifiers

PMID38572959
PMCPMC11064568
OpenAlexW4393934309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.