Evidence map›Paper›PMID 38572865›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hAβ-KI) mice.

Sage J B Dunham, Julio Avelar-Barragan, Jason A Rothman, Eric D Adams, Gina Faraci, Stefania Forner, Shimako Kawauchi, Andrea J Tenner, Kim N Green, Frank M LaFerla and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  8. Article
  9. Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hAβ-KI) mice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Sage J B DunhamDepartment of Molecular Biology & Biochemistry, University of California Irvine, Irvine, California, USA.
Julio Avelar-BarraganDepartment of Molecular Biology & Biochemistry, University of California Irvine, Irvine, California, USA.
Jason A RothmanDepartment of Molecular Biology & Biochemistry, University of California Irvine, Irvine, California, USA.
Eric D AdamsDepartment of Molecular Biology & Biochemistry, University of California Irvine, Irvine, California, USA.
Gina FaraciDepartment of Molecular Biology & Biochemistry, University of California Irvine, Irvine, California, USA.
Stefania FornerInstitute for Memory Impairments and Neurological Disorders (UCI MIND), University of California Irvine, Irvine, California, USA.
Shimako KawauchiDepartment of Anatomy and Neurobiology, Developmental Biology Center, University of California Irvine, College of Medicine, Irvine, California, USA.
Andrea J TennerDepartment of Molecular Biology & Biochemistry, Department of Neurobiology and Behavior, Department of Pathology and Laboratory Medicine, School of Medicine, Institute for Memory Impairments and Neurological Disorders (UCI MIND), University of California Irvine, Irvine, California, USA.
Kim N GreenInstitute for Memory Impairments and Neurological Disorders (UCI MIND), Department of Neurobiology and Behavior, School of Biological Sciences, Center for Neural Circuit Mapping, University of California Irvine, Irvine, California, USA.
Frank M LaFerlaInstitute for Memory Impairments and Neurological Disorders (UCI MIND), Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, USA.
Grant R MacGregorDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, California, USA.
Mark MapstoneDepartment of Neurology, University of California Irvine, Irvine, California, USA.
Katrine L WhitesonDepartment of Molecular Biology & Biochemistry, University of California Irvine, Irvine, California, USA.
University of California, Irvine · US

Funding

UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2017 to 2026
$71.9M
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Training in the Neurobiology of Aging and Alzheimers DiseaseT32AG000096 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI VIVEK SWARUP, Craig E Stark · 1985 to 2026
$9.6M
Hewitt Foundation for Biomedical ResearchNational Cancer Institute of the National Institutes of Health P30CA062203NCI NIH HHS P30 CA062203NIA NIH HHS T32 AG000096NIA NIH HHS T32 AG00096-38NIA NIH HHS U54 AG054349
6 · The paper itself

Abstract

introductionEmerging evidence links changes in the gut microbiome to late-onset Alzheimer's disease (LOAD), necessitating examination of AD mouse models with consideration of the microbiome.

methodsWe used shotgun metagenomics and untargeted metabolomics to study the human amyloid beta knock-in (hAβ-KI) murine model for LOAD compared to both wild-type (WT) mice and a model for early-onset AD (3xTg-AD).

resultsEighteen-month female (but not male) hAβ-KI microbiomes were distinct from WT microbiomes, with AD genotype accounting for 18% of the variance by permutational multivariate analysis of variance (PERMANOVA). Metabolomic diversity differences were observed in females, however no individual metabolites were differentially abundant. hAβ-KI mice microbiomes were distinguishable from 3xTg-AD animals (81% accuracy by random forest modeling), with separation primarily driven by Romboutsia ilealis and Turicibacter species. Microbiomes were highly cage specific, with cage assignment accounting for more than 40% of the PERMANOVA variance between the groups. DISCUSSION: These findings highlight a sex-dependent variation in the microbiomes of hAβ-KI mice and underscore the importance of considering the microbiome when designing studies that use murine models for AD. HIGHLIGHTS: Microbial diversity and the abundance of several species differed in human amyloid beta knock-in (hAβ-KI) females but not males. Correlations to Alzheimer's disease (AD) genotype were stronger for the microbiome than the metabolome. Microbiomes from hAβ-KI mice were distinct from 3xTg-AD mice. Cage effects accounted for most of the variance in the microbiome and metabolome.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesDisease Models, AnimalGenotypeMice, TransgenicAmyloid beta-Protein PrecursorAnimalsFemaleGastrointestinal MicrobiomeGene Knock-In TechniquesHumansMaleMetabolomicsMiceMicrobiotaSex CharacteristicsAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAPP protein, human3xTg‐ADAlzheimer's diseasecage effectshAβ‐KIlate‐onset Alzheimer's diseasemetabolomicsmetagenomicsmicrobiomemouse models for Alzheimer's diseaseTuricibacter

Identifiers

PMID38572865
PMCPMC11247698
OpenAlexW4393934649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.