Evidence map›Paper›PMID 38572823›Full record

ArticleInternational wound journal2024

Identification of IGF2 promotes skin wound healing by co-expression analysis.

Xingyan Liu, Ying Teng, Huan Li, Ding Luo, Hongkun Li, Jinghan Shen, Simin Du, Yuyue Zhang, Dali Wang, Jie Jing

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in International wound journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xingyan LiuSchool and Hospital of Stomatology, Zunyi Medical University, Zunyi, China.ORCID https://orcid.org/0000-0001-5117-0606
Ying TengSchool and Hospital of Stomatology, Zunyi Medical University, Zunyi, China.
Huan LiSchool and Hospital of Stomatology, Zunyi Medical University, Zunyi, China.
Ding LuoSchool and Hospital of Stomatology, Zunyi Medical University, Zunyi, China.
Hongkun LiSchool and Hospital of Stomatology, Zunyi Medical University, Zunyi, China.
Jinghan ShenSchool and Hospital of Stomatology, Zunyi Medical University, Zunyi, China.
Simin DuSchool and Hospital of Stomatology, Zunyi Medical University, Zunyi, China.
Yuyue ZhangSchool and Hospital of Stomatology, Zunyi Medical University, Zunyi, China.
Dali WangDepartment of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Jie JingSchool and Hospital of Stomatology, Zunyi Medical University, Zunyi, China.ORCID https://orcid.org/0009-0001-0538-968X
Zunyi Medical University · CN

Funding

Guizhou Provincial Basic Research Program (Natural Science) ZK[2021]440National Natural Science Foundation of China 32160175The PhD Fund of Scientific Research Foundation of School and Hospital of Stomatology, Zunyi Medical University KY2020-14
6 · The paper itself

Abstract

Oral mucosa is an ideal model for studying scarless wound healing. Researchers have shown that the key factors which promote scarless wound healing already exist in basal state of oral mucosa. Thus, to identify the other potential factors in basal state of oral mucosa will benefit to skin wound healing. In this study, we identified eight gene modules enriched in wound healing stages of human skin and oral mucosa through co-expression analysis, among which the module M8 was only module enriched in basal state of oral mucosa, indicating that the genes in module M8 may have key factors mediating scarless wound healing. Through bioinformatic analysis of genes in module M8, we found IGF2 may be the key factor mediating scarless wound healing of oral mucosa. Then, we purified IGF2 protein by prokaryotic expression, and we found that IGF2 could promote the proliferation and migration of HaCaT cells. Moreover, IGF2 promoted wound re-epithelialization and accelerated wound healing in a full-thickness skin wound model. Our findings identified IGF2 as a factor to promote skin wound healing which provide a potential target for wound healing therapy in clinic.

Indexed as

SkinWound HealingFibroblastsHumansInsulin-Like Growth Factor IIMouth MucosaRe-EpithelializationIGF2 protein, humanInsulin-Like Growth Factor IIco‐expression analysisIGF2oral mucosaskin regenerationwound healing

Identifiers

PMID38572823
PMCPMC10993366
OpenAlexW4393949137

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.