Evidence map›Paper›PMID 38572799›Full record

ArticleCell proliferation2024

Visualization of the hepatic and renal cell uptake and trafficking of tetrahedral DNA origami in tumour.

Shitai Zhu, Hongzhen Peng, Huating Kong, Qinglong Yan, Kai Xia, Lihua Wang, Ying Zhu, Shihua Luo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. In Vivo Interactions of Nucleic Acid Nanostructures With Cells.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shitai ZhuDivision of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Hongzhen PengShanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China.
Huating KongShanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China.ORCID https://orcid.org/0009-0007-4971-9103
Qinglong YanInstitute of Materiobiology, College of Sciences, Shanghai University, Shanghai, China.
Kai XiaXiangfu Laboratory, Jiashan, China.
Lihua WangDivision of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Ying ZhuDivision of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Shihua LuoDepartment of Traumatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Funding

2022 Shanghai "Science and Technology Innovation Action Plan" Fundamental Research Project 22JC1401203National Key R&D Program of China 2023YFC3404200National Natural Science Foundation of China 12005281National Natural Science Foundation of China 12305400National Natural Science Foundation of China 21874043National Natural Science Foundation of China 22022410National Natural Science Foundation of China 22274097National Natural Science Foundation of China 82050005Open Research Fund of the National Facility for Translational Medicine (Shanghai) TMSK-2021-412Science Foundation of the Shanghai Municipal Science and Technology Commission 21dz2210100Shanghai Municipal Science and Technology Major Project 19142202400Shanghai Municipal Science and Technology Major Project 19JC1410300Shanghai Municipal Science and Technology Major Project 2018SHZDZX03Shanghai Science and Technology Development Funds 22QB1404000User Experiment Assist System of Shanghai Synchrotron Radiation Facility (SSRF)
6 · The paper itself

Abstract

DNA nanostructures, known for their programmability, ease of modification, and favourable biocompatibility, have gained widespread application in the biomedical field. Among them, Tetrahedral DNA Origami (TDOs), as a novel DNA nanostructure, possesses well-defined structures, multiple modification sites, and large cavities, making it a promising drug carrier. However, current understanding of TDOs' interactions with biological systems, particularly with target cells and organs, remains unexplored, limiting its further applications in biomedicine. In this work, we prepared TDOs with an average particle size of 40 nm and labelled them with Cy5 fluorescent molecules. Following intravenous injection in mice, the uptake of TDOs by different types of liver and kidney cells was observed. Results indicated that TDOs accumulate in renal tubules and are metabolized by Kupffer cells, epithelial cells, and hepatocytes in the liver. Additionally, in a tumour-bearing mouse model, TDOs passively targeted tumour tissues and exhibited excellent tumour penetration and retention after rapid metabolism in hepatocytes. Our findings provide crucial insights for the development of TDO-based drug delivery systems.

Indexed as

DNAKidneyLiverNanostructuresAnimalsCarbocyaninesCell Line, TumorHepatocytesHumansMiceMice, Inbred BALB CCarbocyaninescyanine dye 5DNA

Identifiers

PMID38572799
PMCPMC11294413

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.