Evidence map›Paper›PMID 38572608›Full record

ArticleCurrent pharmaceutical biotechnology2024

The Treatment of Tubal Inflammatory Infertility using Yinjia Tablets through EGFR/MEK/ERK Signaling Pathway based on Network Pharmacology.

Yefang Huang, Zhelin He, Hang Zhou, Yi Wen, Xiaoli Ji, Weijun Ding, Boyu Zhu, Yongqing Zhang, Ying Tan, Kun Yang and 1 more

Abstract read
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In one paragraph

Article in Current pharmaceutical biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yefang HuangHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Zhelin HeGuang'an Traditional Chinese Medicine Hospital, Guang'an, Sichuan, China.
Hang ZhouSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Yi WenHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Xiaoli JiHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Weijun DingSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Boyu ZhuHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Yongqing ZhangHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Ying TanHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Kun YangSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Yan WangHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Chengdu University of Traditional Chinese Medicine · CNGuang’anmen Hospital · CN

Funding

Sichuan Provincial Administration of Traditional Chinese Medicine Scientific Research Project 2020JC0046Sichuan Science and Technology Program 2022YFS0415
6 · The paper itself

Abstract

<p>Background: Salpingitis obstructive infertility (SOI) refers to infertility caused by abnormal conditions such as tubal adhesion and blockage caused by acute and chronic salpingitis. SOI has a serious impact on women's physical and mental health and family harmony, and it is a clinical problem that needs to be solved urgently. <p> Objective: The purpose of the present study was to explore the potential pharmacological mechanisms of the Yinjia tablets (Yin Jia Pian, YJP) on tubal inflammation. <p> Methods: Networks of YJP-associated targets and tubal inflammation-related genes were constructed through the STRING database. Potential targets and pathway enrichment analysis related to the therapeutic efficacy of YJP were identified using Cytoscape and Database for Annotation, Visualization, and Integrated Discovery (metascape).

Indexed as

Drugs, Chinese HerbalInfertilitySalpingitisAnimalsErbB ReceptorsEscherichia coliFemaleHumansInflammationInterleukin-6MAP Kinase Signaling SystemMitogen-Activated Protein Kinase KinasesNetwork PharmacologyProto-Oncogene Proteins c-bcl-2RatsSignal TransductionDrugs, Chinese HerbalEGFR protein, humanErbB ReceptorsInterleukin-6Mitogen-Activated Protein Kinase KinasesProto-Oncogene Proteins c-bcl-2Tumor Necrosis Factor-alphaEGFR signaling pathwayESR1network pharmacologySTRING database.tubal inflammationYin jia tablet

Identifiers

PMID38572608
OpenAlexW4387772049

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.