Evidence map›Paper›PMID 38572510›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Ionic Liquid Coating-Driven Nanoparticle Delivery to the Brain: Applications for NeuroHIV.

Christine M Hamadani, Fakhri Mahdi, Anya Merrell, Jack Flanders, Ruofan Cao, Priyavrat Vashisth, Gaya S Dasanayake, Donovan S Darlington, Gagandeep Singh, Mercedes C Pride and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Ionic Liquid Coating-Driven Nanoparticle Delivery to the Brain: Applications for NeuroHIV.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Christine M HamadaniDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
Fakhri MahdiDepartment of BioMolecular Sciences, The University of Mississippi, University, MS, 38677, USA.
Anya MerrellDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
Jack FlandersDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
Ruofan CaoDepartment of BioMolecular Sciences, The University of Mississippi, University, MS, 38677, USA.
Priyavrat VashisthDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
Gaya S DasanayakeDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
Donovan S DarlingtonDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
Gagandeep SinghDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
Mercedes C PrideDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
Wake G MonroeDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
George R TaylorDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
Alysha N HunterDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.
Gregg RomanDepartment of BioMolecular Sciences, The University of Mississippi, University, MS, 38677, USA.
Jason J ParisDepartment of BioMolecular Sciences, The University of Mississippi, University, MS, 38677, USA.
Eden E L TannerDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, 38677, USA.ORCID 0000-0002-7919-2249
University of Mississippi · US

Funding

Tracking Glycosylation State with Fluorinated Glycosides ProbesP20GM130460 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI Joshua S Sharp · 2020 to 2026
$17.9M
Pilot Project ProgramP30GM122733 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI MAJUMDAR, SOUMYAJIT · 2018 to 2022
$5.3M
Ionic liquid-assisted drug delivery to brain reservoirs for treatment of neuroHIVR01DA056875 · NIDA · UNIVERSITY OF MISSISSIPPI · PI Jason Richard Paris, Eden Tanner · 2023 to 2026
$2.2M
Laser spectroscopic instrumentation for isotopic sensing of biogenic Nitric OxideR21GM103460 · NIGMS · PRINCETON UNIVERSITY · PI WYSOCKI, GERARD · 2012 to 2012
$190k
College of Liberal Arts at the University of MississippiNational Science Foundation 1726880National Science Foundation 2236629NIDA NIH HHS R01 DA056875NIGMS NIH HHS P20 GM130460NIGMS NIH HHS P30 GM122733NIGMS NIH HHS R21 GM103460NIH HHS P20GM103460NIH HHS P30GM122733NIH HHS R01DA056875Pharmaceutical Research and Manufacturers of America Foundation (PhRMA)Sigma Xi Grants in Aid of Research G0315202198510166University of Mississippi iDRUM Initiative
6 · The paper itself

Abstract

Delivering cargo to the central nervous system (CNS) remains a pharmacological challenge. For infectious diseases such as HIV, the CNS acts as a latent reservoir that is inadequately managed by systemic antiretrovirals (ARTs). ARTs thus cannot eradicate HIV, and given CNS infection, patients experience neurological deficits collectively referred to as "neuroHIV". Herein, the development of bioinspired ionic liquid-coated nanoparticles (IL-NPs) for in situ hitchhiking on red blood cells (RBCs) is reported, which enables 48% brain delivery of intracarotid arterial- infused cargo. Moreover, IL choline trans-2-hexenoate (CA2HA 1:2) demonstrates preferential accumulation in parenchymal microglia over endothelial cells post-delivery. This study further demonstrates successful loading of abacavir (ABC), an ART that is challenging to encapsulate, into IL-NPs, and verifies retention of antiviral efficacy in vitro. IL-NPs are not cytotoxic to primary human peripheral blood mononuclear cells (PBMCs) and the CA2HA 1:2 coating itself confers notable anti-viremic capacity. In addition, in vitro cell culture assays show markedly increased uptake of IL-NPs into neural cells compared to bare PLGA nanoparticles. This work debuts bioinspired ionic liquids as promising nanoparticle coatings to assist CNS biodistribution and has the potential to revolutionize the delivery of cargos (i.e., drugs, viral vectors) through compartmental barriers such as the blood-brain-barrier (BBB).

Indexed as

Anti-HIV AgentsBrainHIV InfectionsIonic LiquidsNanoparticle Drug Delivery SystemAbacavirAnimalsAnti-Retroviral AgentsCarotid ArteriesCentral Nervous SystemDrug CompoundingErythrocytesHIVHumansInjections, Intra-ArterialMiceAbacavirAnti-HIV AgentsAnti-Retroviral AgentsIonic LiquidsNanoparticle Drug Delivery SystemPolyethylene Glycolsbrain deliverycellular hitchhikingionic liquidsnanoparticlesred blood cells

Identifiers

PMID38572510
PMCPMC11186118
OpenAlexW4393942944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.