Evidence map›Paper›PMID 38572314›Full record

ArticleFrontiers in cellular and infection microbiology2024

Katharine A Barrett, Francis Jacob Kassama, William Surks, Andrew J Mulholland, Karen D Moulton, Danielle H Dube

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. AssessingACS infectious diseases · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Katharine A BarrettDepartment of Chemistry & Biochemistry, Bowdoin College, Brunswick, ME, United States.
Francis Jacob KassamaDepartment of Chemistry & Biochemistry, Bowdoin College, Brunswick, ME, United States.
William SurksDepartment of Chemistry & Biochemistry, Bowdoin College, Brunswick, ME, United States.
Andrew J MulhollandDepartment of Chemistry & Biochemistry, Bowdoin College, Brunswick, ME, United States.
Karen D MoultonDepartment of Chemistry & Biochemistry, Bowdoin College, Brunswick, ME, United States.
Danielle H DubeDepartment of Chemistry & Biochemistry, Bowdoin College, Brunswick, ME, United States.
Bowdoin College · US

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI JAMES A COFFMAN · 2012 to 2026
$60.0M
Deciphering Helicobacter pylori's glycocode: uncovering & harnessing drug targetsR15GM109397 · NIGMS · BOWDOIN COLLEGE · PI DUBE, DANIELLE H. · 2015 to 2021
$1.1M
NIGMS NIH HHS P20 GM103423NIGMS NIH HHS R15 GM109397
6 · The paper itself

Abstract

Introduction: The pathogenic bacterium Methods: To test this hypothesis, human cell lines were challenged with wildtype Results: Our findings indicate that disruption of lipopolysaccharide biosynthesis diminishes gastric cytokine production, without disrupting dendritic cell recognition and activation. In contrast, variable immune responses were observed in protein glycosylation mutants which prompted us to test the hypothesis that phase variation plays a role in regulating bacterial cell surface glycosylation and subsequent immune recognition. Lewis antigen presentation does not correlate with extent of immune response, while the extent of lipopolysaccharide O-antigen elaboration does. Discussion: The outcomes of this study demonstrate that

Indexed as

Helicobacter InfectionsHelicobacter pyloriCytokinesGastric MucosaHumansLipopolysaccharidesPolysaccharidesStomachCytokinesLipopolysaccharidesPolysaccharidesglycanglycosylation mutantHelicobacter pyloriimmunologymetabolic labelingphase variation

Identifiers

PMID38572314
PMCPMC10987845
OpenAlexW4393012541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.