Social relationships, amyloid burden, and dementia: The ARIC-PET study.
Renée C Groechel, Albert C Liu, Chelsea Liu, David S Knopman, Silvia Koton, Anna M Kucharska-Newton, Pamela L Lutsey, Thomas H Mosley, Priya Palta, A Richey Sharrett and 3 more
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors at 8 institutions in 2 countries.
Renée C GroechelNational Institute of Neurological Disorders & Stroke Intramural Research Program National Institutes of Health Bethesda Maryland USA.ORCID https://orcid.org/0000-0002-1771-5171
Albert C LiuDepartment of Epidemiology University of North Carolina Gillings School of Global Public Health Chapel Hill North Carolina USA.
Chelsea LiuDepartment of Epidemiology George Washington University-Milken Institute School of Public Health Washington District of Columbia USA.
David S KnopmanDepartment of Neurology Mayo Clinic Rochester Minnesota USA.
Silvia KotonDepartment of Nursing The Stanley Steyer School of Health Professions Tel Aviv University Tel Aviv Israel.
Anna M Kucharska-NewtonDepartment of Epidemiology University of North Carolina Gillings School of Global Public Health Chapel Hill North Carolina USA.
Pamela L LutseyDivision of Epidemiology and Community Health University of Minnesota School of Public Health Minneapolis Minnesota USA.
Thomas H MosleyDepartment of Medicine University of Mississippi Medical Center Jackson Mississippi USA.
Priya PaltaDepartment of Neurology University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
A Richey SharrettDepartment of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore Maryland USA.
Keenan A WalkerNational Institute on Aging Intramural Research Program National Institutes of Health Bethesda Maryland USA.
Dean F WongMallinckrodt Institute of Radiology Washington University St. Louis Missouri USA.
Rebecca F GottesmanNational Institute of Neurological Disorders & Stroke Intramural Research Program National Institutes of Health Bethesda Maryland USA.
National Institutes of Health · USUniversity of North Carolina at Chapel Hill · USJohns Hopkins University · USMayo Clinic · USMilken Institute · USUniversity of Minnesota · USUniversity of Mississippi Medical Center · USWashington University in St. Louis · US
Funding
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
Stroke, Cognition and Neuroepidemiology SectionZIANS009435 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOTTESMAN, REBECCA F · 2022 to 2025
$8.2M
ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5M
ARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4M
The ARIC-PET Amyloid Imaging StudyR01AG040282 · NIA · JOHNS HOPKINS UNIVERSITY · PI CORESH, JOSEF, SPIRA, ADAM PETER · 2011 to 2021
$7.1M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5U01HL096814 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M., WAGENKNECHT, LYNNE E · 2010 to 2018
$6.5M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00003 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2022 to 2025
$5.1M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE · 2022 to 2025
$5.0M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00004 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI WINDHAM, BEVERLY GWEN · 2022 to 2025
$4.8M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00002 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ARGANI, PEDRAM · 2022 to 2025
introductionThis study aimed to assess whether social relationships in mid-life reduce the risk of dementia related to amyloid burden.
methodsParticipants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (visit 2; 1990-1992). A composite measure, "social relationships," was generated. Brain amyloid was evaluated with florbetapir positron emission tomography (PET); (visit 5; 2012-2014). Incident dementia cases were identified following visit 5 through 2019 using ongoing surveillance. Relative contributions of mid-life social relationships and elevated brain amyloid to incident dementia were evaluated with Cox regression models.
resultsAmong 310 participants without dementia, strong mid-life social relationships were associated independently with lower dementia risk. Elevated late-life brain amyloid was associated with greater dementia risk. DISCUSSION: Although mid-life social relationships did not moderate the relationship between amyloid burden and dementia, these findings affirm the importance of strong social relationships as a potentially protective factor against dementia.
Indexed as
amyloid betaAtherosclerosis Risk in Communities studydementiamid‐lifepositron emission tomographysocial relationships
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Social relationships, amyloid burden, and dementia: The ARIC-PET study. · full record | OpenQuestion