Evidence map›Paper›PMID 38571932›Full record

ArticleRheumatology and immunology research2024

Clinical implications of seropositive and seronegative autoantibody status in rheumatoid arthritis patients: A comparative multicentre observational study.

Nevin Hammam, Passant N El-Husseiny, Suzan S Al-Adle, Nermeen Samy, Nora Y Elsaid, Dina F El-Essawi, Eman F Mohamed, Samar M Fawzy, Samah A El Bakry, Maha Nassr and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology and immunology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Observational
  2. Article
  3. ElevatedJournal of inflammation research · 2025
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Nevin HammamRheumatology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Passant N El-HusseinyRheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Suzan S Al-AdleRheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Nermeen SamyInternal Medicine Department, Rheumatology Unit, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Nora Y ElsaidRheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Dina F El-EssawiHealth Radiation Research Department, Internal Medicine Unit, Rheumatology Clinic, (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
Eman F MohamedInternal Medicine Department, Rheumatology Unit, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt.
Samar M FawzyRheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Samah A El BakryInternal Medicine Department, Rheumatology Unit, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Maha NassrRheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Samah I NasefRheumatology Department, Faculty of Medicine, Suez-Canal University, Ismailia, Egypt.
Hanan M El-SaadanyRheumatology Department, Faculty of Medicine, Tanta University, Gharbia, Egypt.
Shereen ElwanRheumatology Department, Faculty of Medicine, Tanta University, Gharbia, Egypt.
Nada M GamalRheumatology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Abdelhfeez MoshrifRheumatology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Osman HammamDepartment of Rheumatology and Rehabilitation, Faculty of Medicine, New Valley University, New Valley, Egypt.
Rawhya R El ShereefRheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt.
Faten IsmailRheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt.
Samar TharwatInternal Medicine Department, Rheumatology Unit, Faculty of Medicine, Mansoura University, Dakahlia, Egypt.
Doaa Mosad MosaDepartment of Rheumatology and Rehabilitation, Mansoura University Hospitals, Mansoura University Faculty of Medicine, Mansoura, Egypt.
Mervat I Abd ElazeemRheumatology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Enas A AbdelaleemRheumatology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Tamer A GheitaRheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Egyptian College of Rheumatology (ECR) Rheumatoid Arthritis (ECR-RA) Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Rheumatoid factor (RF) and anti-cyclic citrullinated protein (anti-CCP) have been used to improve the diagnosis and prognosis of rheumatoid arthritis (RA). However, their association with RA disease phenotypes, individually and in combination, is not well studied. The aim of the study was to compare patients' and disease characteristics, activity and severity in double seronegative (DNRA), single seropositive RF, single seropositive anti-CCP and double seropositive (DPRA) patients. Methods: Adults subjects with RA from Egyptian College of Rheumatology (ECR) database who had RF and anti-CCP results available were included. Demographic, clinical features, disease activity score 28 (DAS28), Health Assessment Questionnaire (HAQ) and laboratory data were collected and compared among different RA groups. Results: 5268 RA patients with mean age of 44.9±11.6 years, and 4477 (85%) were females. 2900 (55%) had DPRA, 892 (16.9%) had single positive RF, 597 (11.3%) had single positive anti-CCP while 879 (16.7%) had DNRA. Patients with DPRA had significantly high percentage of metabolic syndrome (19.3%, Conclusion: Dual antibody-positive status has higher disease activity and severity, and higher chance of development of metabolic syndrome; highlighting the implicated role of inflammation, atherogenesis and cardiovascular disease risk in RA.

Indexed as

anti-cyclic citrullinated peptideegyptian college of rheumatologyrheumatoid arthritisrheumatoid factor

Identifiers

PMID38571932
PMCPMC10985701

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.