Evidence map›Paper›PMID 38571360›Full record

SynthesisCurrent cardiology reviews2024

Pro- and Anti-inflammatory Biomarkers Responses after Aerobic Training in Heart Transplant Recipients: A Systematic Review and Meta-analysis.

Leandro Tolfo Franzoni, Stephanie Bastos da Motta, Gabriel Carvalho, Rochelle Rocha Costa, Mabel Marciela Ahner, Marco Aurélio Lumertz Saffi, Alexandre Araújo Pereira, Adamastor Humberto Pereira, Anderson Donelli da Silveira, Ricardo Stein

Open access · greenAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Current cardiology reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Leandro Tolfo FranzoniPrograma de Pós-graduação em Ciências da Saúde: Cardiologia e Ciências Cardiovasculares da Universidade Federal do Rio Grande do Sul - Porto Alegre, Brazil.ORCID 0000-0002-6327-1428
Stephanie Bastos da MottaPrograma de Pós-graduação em Ciências da Saúde: Cardiologia e Ciências Cardiovasculares da Universidade Federal do Rio Grande do Sul - Porto Alegre, Brazil.
Gabriel CarvalhoPrograma de Pós-graduação em Ciências da Saúde: Cardiologia e Ciências Cardiovasculares da Universidade Federal do Rio Grande do Sul - Porto Alegre, Brazil.
Rochelle Rocha CostaGrupo de Pesquisa em Cardiologia do Exercício do Hospital de Clínicas de Porto Alegre - Porto Alegre, Brazil.
Mabel Marciela AhnerUniversidade Federal do Rio Grande do Sul, Porto Alegre-RS, Brazil.
Marco Aurélio Lumertz SaffiPrograma de Pós-graduação em Ciências da Saúde: Cardiologia e Ciências Cardiovasculares da Universidade Federal do Rio Grande do Sul - Porto Alegre, Brazil.
Alexandre Araújo PereiraUniversidade Federal do Rio Grande do Sul, Porto Alegre-RS, Brazil.
Adamastor Humberto PereiraUniversidade Federal do Rio Grande do Sul, Porto Alegre-RS, Brazil.
Anderson Donelli da SilveiraPrograma de Pós-graduação em Ciências da Saúde: Cardiologia e Ciências Cardiovasculares da Universidade Federal do Rio Grande do Sul - Porto Alegre, Brazil.
Ricardo SteinPrograma de Pós-graduação em Ciências da Saúde: Cardiologia e Ciências Cardiovasculares da Universidade Federal do Rio Grande do Sul - Porto Alegre, Brazil.
Universidade Federal do Rio Grande do Sul · BRUniversidade de Brasília · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhysical exercise (PE) may improve plasma concentration of interleukin- 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and adiponectin (adpN) in heart transplant (HT) patients. However, no consistent data is available on this population.

aimThus, we aimed to conduct a systematic review and meta-analysis on the effects of PE over these pro- and anti-inflammatory biomarkers in HT patients.

methodsFollowing the guidelines established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement, we conducted a systematic literature search in the PubMed, Cochrane, and Scopus databases. Outcomes included IL-6, TNF-alpha, and adpN. Effect size (ES) was calculated using the standardized mean difference with a 95% confidence interval (CI).

resultsThe PE group (aerobic modality) was associated with reduced IL-6 compared to the control group (ES: -0.53; 95% CI: -0.99 to -0.06 pg/mL; P = 0.026). However, the PE group did not show a significant effect on TNF-alpha and adpN levels (ES: -0.33; 95% CI: -0.79 to 0.13; P = 0.16 and ES: -0.20; 95% CI: -0.70 to 0.30 pg/mL; P = 0.444, respectively).

conclusionPE is associated with IL-6 reductions, although TNF alpha and adpN did not change after this intervention in HT patients. Therefore, PE is an effective intervention to downregulate IL-6 in post-HT patients.

Indexed as

BiomarkersExerciseHeart TransplantationInflammationAdiponectinExercise TherapyHumansInflammation MediatorsInterleukin-6Tumor Necrosis Factor-alphaAdiponectinBiomarkersInflammation MediatorsInterleukin-6Tumor Necrosis Factor-alphaaerobic modalitybiomarkersheart transplant.inflammationinterleukin-6Transplant

Identifiers

PMID38571360
PMCPMC11337611
OpenAlexW4393947903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.