ArticleEpigenetics2024
Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations.
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Article in Epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
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Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- Longitudinal Changes in Inflammation-Related Methylation Risk Score for C-Reactive Protein Among People with HIV.Epigenomes · 2026Article
- A New Complexity Layer: DNA Methylation and the Predictive Impact of Epigenetic Tests.International journal of molecular sciences · 2026Review
- Association of DNA methylation with hypertension and blood pressure: a 7-year longitudinal study from KORA F4/FF4.BMC medicine · 2026Article
- DNA Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study.Journal of the American Heart Association · 2025Article
- Trace element-linked DNA methylation sites and their association with type 2 diabetes and cardiovascular diseases: EPIC-Potsdam cohort study.Clinical epigenetics · 2025Article
- Epigenetic Age Monitoring in Professional Soccer Players for Tracking Recovery and the Effects of Strenuous Exercise.Aging cell · 2025Observational
- Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease.Atherosclerosis · 2025Article
- Multi-omics analysis reveals novel causal pathways in psoriasis pathogenesis.Journal of translational medicine · 2025Article
- Article
Corrections and comments
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Authors and funding
40 authors at 19 institutions in 1 country.
Jessica I LundinDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0003-4892-6235
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Yao HuDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Farah AmmousDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Christy L AveryDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Emelia J BenjaminBoston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0003-4076-2336
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Chris CarlsonDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Mary CushmanDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.
Chris GignouxInterdisciplinary Quantitative Biology, University of Colorado, Boulder, CO, USA.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Jeff HaesslerDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Chris HaimanDepartment of Environmental Medicine and Public Health, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Roby JoehanesPopulation Sciences Branch, National Heart, Lung, and Blood Institute of the National Institutes of Health, Bethesda, MD, USA.
Silva KaselaNew York Genome Center, New York, NY.ORCID 0000-0003-4362-0034
Eimear KennyIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Tuuli LapalainienNew York Genome Center, New York, NY.ORCID 0000-0002-7746-8109
Daniel LevyPopulation Sciences Branch, National Heart, Lung, and Blood Institute of the National Institutes of Health, Bethesda, MD, USA.
Chunyu LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Yongmei LiuDuke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Ruth J F LoosIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Ake LuDepartment of Human Genetics, University of California LA, Los Angeles, CA, USA.
Tara MatiseDepartment of Genetics, Rutgers University, New Brunswick, NJ, USA.
Kari E NorthDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Sungshim L ParkEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Scott M RatliffDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Alex ReinerDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-3872-7793
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, and Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Nona SotoodehniaCardiovascular Health Research Unit, Harborview Medical Center, Seattle, WA, USA.
Russell TracyDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
David Van den BergDepartment of Environmental Medicine and Public Health, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Huichun XuDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Ting YeDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Wei ZhaoSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
PAGE Study
Fred Hutch Cancer Center · USUniversity of Michigan · USUniversity of Washington · USUniversity of North Carolina at Chapel Hill · USBoston University · USIcahn School of Medicine at Mount Sinai · USNational Institutes of Health · USNew York Genome Center · USUCLA Medical Center · USUniversity of Southern California · USUniversity of Vermont · USDuke University · USHarborview Medical Center · USRutgers, The State University of New Jersey · USUniversity of California, Los Angeles · USUniversity of Colorado Boulder · USUniversity of Hawaiʻi at Mānoa · USUniversity of Maryland, Baltimore · USUniversity of Virginia · US
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MWOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MFRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MIDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
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Abstract
Systemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflammation in disease is not completely understood. Methylation is an epigenetic modification in the DNA which plays a pivotal role in gene expression. In this study we evaluated differential DNA methylation patterns associated with blood CRP level to elucidate biological pathways and genetic regulatory mechanisms to improve the understanding of chronic inflammation. The racially and ethnically diverse participants in this study were included as 50% White, 41% Black or African American, 7% Hispanic or Latino/a, and 2% Native Hawaiian, Asian American, American Indian, or Alaska Native (total
Indexed as
C-Reactive ProteinDNA MethylationCpG IslandsDNAEpigenesis, GeneticGenome-Wide Association StudyHumansInflammationIntracellular Signaling Peptides and ProteinsC-Reactive ProteinDNAIntracellular Signaling Peptides and ProteinsNLRC5 protein, humancausal pathwayC-reactive proteinepigeneticsEWASInflammationMendelian randomizationmethylationracial and ethnic diversity
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