Evidence map›Paper›PMID 38570814›Full record

ArticleAngewandte Chemie (International ed. in English)2024

PyrAtes: Modular Organic Salts with Large Stokes Shifts for Fluo-rescence Microscopy.

Iakovos Saridakis, Margaux Riomet, Oliver J V Belleza, Guilhem Coussanes, Nadja K Singer, Nina Kastner, Yi Xiao, Elliot Smith, Veronica Tona, Aurélien de la Torre and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. In Situ Construction of Imidazopyridinium Fluorescent Labels for Bioconjugation.Angewandte Chemie (International ed. in English) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Iakovos SaridakisInstitute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090, Vienna, Austria.ORCID 0000-0002-2690-5401
Margaux RiometInstitute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090, Vienna, Austria.ORCID 0000-0002-3444-5652
Oliver J V BellezaCentre of Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, Schwarzspanierstraße 17A, 1090, Vienna, Austria.ORCID 0000-0002-6383-6636
Guilhem CoussanesInstitute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090, Vienna, Austria.
Nadja K SingerInstitute of Theoretical Chemistry, University of Vienna, Währinger Strasse 17, 1090, Vienna, Austria.ORCID 0000-0001-9938-7900
Nina KastnerCentre of Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, Schwarzspanierstraße 17A, 1090, Vienna, Austria.ORCID 0000-0002-1576-9029
Yi XiaoInstitute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090, Vienna, Austria.
Elliot SmithInstitute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090, Vienna, Austria.
Veronica TonaInstitute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090, Vienna, Austria.
Aurélien de la TorreInstitute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090, Vienna, Austria.ORCID 0000-0002-7909-0234
Eric F LopesInstitute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090, Vienna, Austria.
Pedro A Sánchez-MurciaInstitute of Theoretical Chemistry, University of Vienna, Währinger Strasse 17, 1090, Vienna, Austria.
Leticia GonzálezInstitute of Theoretical Chemistry, University of Vienna, Währinger Strasse 17, 1090, Vienna, Austria.ORCID 0000-0001-5112-794X
Harald H SitteCentre of Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, Schwarzspanierstraße 17A, 1090, Vienna, Austria.ORCID 0000-0002-1339-7444
Nuno MaulideInstitute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090, Vienna, Austria.ORCID 0000-0003-3643-0718
University of Vienna · ATSmall Business Administration · USAl-Ahliyya Amman University · JOEquilibrium Research · GBMedical University of Vienna · AT

Funding

Austrian Science Fund P33955Austrian Science Fund W1232H2020 European Research Council CoG 682002
6 · The paper itself

Abstract

The deployment of small-molecule fluorescent agents plays an ever-growing role in medicine and drug development. Herein, we complement the portfolio of powerful fluorophores, reporting the serendipitous discovery and development of a novel class with an imidazo[1,2-a]pyridinium triflate core, which we term PyrAtes. These fluorophores are synthesized in a single step from readily available materials (>60 examples) and display Stokes shifts as large as 240 nm, while also reaching NIR-I emissions at λ

Indexed as

Fluorescent DyesHEK293 CellsHumansMicroscopy, FluorescenceMolecular StructureSaltsFluorescent DyesSaltsDyesFluorescenceFluorophoreImidazo[1,2-a]pyridiniumStokes shift

Identifiers

PMID38570814
PMCPMC11497256
OpenAlexW4393946374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.