Evidence map›Paper›PMID 38570751›Full record

ArticleBMC pulmonary medicine2024

Genetic association between smoking and DLCO in idiopathic pulmonary fibrosis patients.

Ziheng Yuan, Wanyang Lei, Xiqian Xing, Xiaohua He, Xiaoxian Huang, Li Wei, Yuanyuan Lv, Shuyi Qiu, Ziyu Yuan, Jiyang Wang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ziheng Yuan *Department of Clinical Laboratory, Yunnan Molecular Diagnostic Center, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Wanyang Lei *Department of Clinical Laboratory, Yunnan Molecular Diagnostic Center, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Xiqian XingDepartment of Respiratory and Critical Care, Affiliated Hospital of Yunnan University, Kunming, China.
Xiaohua HeDepartment of Respiratory and Critical Care, Affiliated Hospital of Yunnan University, Kunming, China.
Xiaoxian HuangDepartment of Respiratory and Critical Care, Affiliated Hospital of Yunnan University, Kunming, China.
Li WeiDepartment of Respiratory and Critical Care, Affiliated Hospital of Yunnan University, Kunming, China.
Yuanyuan LvDepartment of Respiratory and Critical Care, Affiliated Hospital of Yunnan University, Kunming, China.
Shuyi QiuDepartment of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Ziyu YuanDepartment of Clinical Laboratory Medicine, Yunnan Cancer Hospital, Yunnan Cancer Center, The Third Affiliated Hospital of Kunming Medical University, 650118, Kunming, China.
Jiyang WangDepartment of Cardiovascular Surgery, Affiliated Hospital of Yunnan University, Kunming, China. wjy0304@ynu.edu.cn.
Mei YangDepartment of Respiratory and Critical Care, Affiliated Hospital of Yunnan University, Kunming, China. 57459664@qq.com.
Yunnan University · CNKunming Medical University · CN

Funding

Basic Research Program of Science and Technology Project of Yunnan Science and Technology Department 202101AY070001-285Basic Research Program of Science and Technology Project of Yunnan Science and Technology Department 202101AY070001-286Famous Doctors of High-level Talent Training Support Program of Yunnan Province YNWR-MY-2020-013
6 · The paper itself

Abstract

backgroundObservational studies have shown that smoking is related to the diffusing capacity of the lungs for carbon monoxide (DLCO) in individuals with idiopathic pulmonary fibrosis (IPF). Nevertheless, further investigation is needed to determine the causal effect between these two variables. Therefore, we conducted a study to investigate the causal relationship between smoking and DLCO in IPF patients using two-sample Mendelian randomization (MR) analysis.

methodsLarge-scale genome-wide association study (GWAS) datasets from individuals of European descent were analysed. These datasets included published lifetime smoking index (LSI) data for 462,690 participants and DLCO data for 975 IPF patients. The inverse-variance weighting (IVW) method was the main method used in our analysis. Sensitivity analyses were performed by MR‒Egger regression, Cochran's Q test, the leave-one-out test and the MR-PRESSO global test.

resultsA genetically predicted increase in LSI was associated with a decrease in DLCO in IPF patients [OR

conclusionsOur study suggested that smoking is associated with a decrease in DLCO. Patients diagnosed with IPF should adopt an active and healthy lifestyle, especially by quitting smoking, which may be effective at slowing the progression of IPF.

Indexed as

Genome-Wide Association StudyIdiopathic Pulmonary FibrosisCarbon MonoxideHumansSmokingTobacco SmokingCarbon MonoxideCausal effectDiffusing capacity of the lungs for carbon monoxide (DLCO)Idiopathic pulmonary fibrosis (IPF)Mendelian randomization (MR)Smoking

Identifiers

PMID38570751
PMCPMC10993445
OpenAlexW4393903018

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.