ArticleNature2024
Improving prime editing with an endogenous small RNA-binding protein.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers, 2 of them syntheses that pooled it.
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178citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
178 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Pooled it
- Role of Chromatin-Associated RNAs in Eye Physiology and Pathology.Methods in molecular biology (Clifton, N.J.) · 2027Review
- Prime Editing: An Overview.Methods in molecular biology (Clifton, N.J.) · 2027Review
- Efficient PE system PE7-scFv-MLH1dn by optimizing the configuration of La and MLH1dn.Synthetic and systems biotechnology · 2026Article
- cPRIME enables endogenous mapping of genetic variant effects at RNA level.Nature communications · 2026Article
- Evaluating Plasma-Handling Effects on Extracellular Vesicle RNA Yield and Cargo Profiles in Fish: A Methodological Insight.Journal of extracellular biology · 2026Article
- Advances in Precision Editing Therapies for Alpha-1 Antitrypsin Deficiency.Human gene therapy · 2026Review
- Editing around the target: epitope engineering to protect stem cell grafts.Blood advances · 2026Review
- Dense RNA motif modifications enable robust in vivo prime editing and enhance efficiencies of diverse editing systems.Nature biomedical engineering · 2026Article
- Optimizing twin prime editing components for scalable genome editing and therapy in spinocerebellar ataxia type 3.Molecular therapy. Nucleic acids · 2026Article
- Enhanced γ-globin reactivation and sickle cell correction through a repressor-to-activator motif switch in theMolecular therapy. Nucleic acids · 2026Article
- Recent Advances in CRISPR/Cas Technologies for Biological Discovery, Therapeutics, and Diagnostics.Biomolecules · 2026Review
- Article
- Multichannel genomic recording of biological information with ENGRAM.Nature protocols · 2026Review
- Article
- Strategies and mechanisms of precision genome engineering: From gene editing to genome writing.iMetaOmics · 2026Review
- Advances in prime editing: Molecular innovations, Large-fragment engineering, and AI-driven design.Biodesign research · 2026Review
- Precise genomic integration of large DNA fragments by donor-directed annealing using prime editing.Nature biotechnology · 2026Article
- Donor-complementary prime editing enables precise kilobase and library-compatible DNA insertions.Nature biotechnology · 2026Article
118 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Jun YanDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID 0009-0005-9139-3966
Paul Oyler-CastrilloLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Purnima RavisankarLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0001-7799-4558
Carl C WardGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Sébastien LevesqueDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.
Yangwode JingDepartment of Chemistry, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-1692-6567
Danny SimpsonLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Anqi ZhaoDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Hui LiDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Weihao YanDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID 0009-0000-2509-1816
Laine GoudyGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Ralf SchmidtGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.ORCID 0000-0002-6697-0363
Sabrina C SolleyDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-2356-5608
Luke A GilbertArc Institute, Palo Alto, CA, USA.ORCID 0000-0001-5854-0825
Michelle M ChanDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID 0000-0001-9451-9716
Daniel E BauerDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.
Alexander MarsonGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.ORCID 0000-0002-2734-5776
Lance R ParsonsLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-8521-714X
Britt AdamsonDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA. badamson@princeton.edu.ORCID 0000-0002-9451-5819
Funding
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4MCenter for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human DiseaseRM1HG009490 · NHGRI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI Brittany S. Adamson, Martin Joseph Ankrah Aryee · 2017 to 2026
$22.7MQuantitavie and Computational Biology Graduate ProgramT32HG003284 · NHGRI · PRINCETON UNIVERSITY · PI Joshua Michael Akey, Stanislav Y. Shvartsman · 2004 to 2026
$9.9MStem Cell and Transplantation BiologyU54DK106829 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DEREK L STIREWALT · 2015 to 2026
$9.1MPROMINENT - UCSFOT2CA278665 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALLAN BALMAIN · 2022 to 2026
$8.9MSpatial multiomic mapping of gene function with CRISPRoffUM1HG012660 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Luke Gilbert · 2022 to 2026
$8.2MRectifying splicing mutations in blood disorders by gene editingR01HL150669 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI BAUER, DANIEL EVAN, WOLFE, SCOT A · 2020 to 2023
$3.5MMapping the DNA damage response in human cells with high-resolution functional genomicsR35GM138167 · NIGMS · PRINCETON UNIVERSITY · PI Brittany S. Adamson · 2020 to 2026
$2.4MA GENETIC INTERACTION MAP OF THE HUMAN NUCLEUSDP2CA239597 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GILBERT, LUKE · 2018 to 2018
$2.4MExpanding the scope of protein degradation and stability using chemoproteomic platformsK00CA245718 · NCI · J. DAVID GLADSTONE INSTITUTES · PI WARD, CARL · 2021 to 2024
$371kNCI NIH HHS DP2 CA239597NCI NIH HHS K00 CA245718NCI NIH HHS OT2 CA278665NHGRI NIH HHS RM1 HG009490NHGRI NIH HHS T32 HG003284NHGRI NIH HHS UM1 HG012660NHLBI NIH HHS R01 HL150669NIDDK NIH HHS U54 DK106829NIGMS NIH HHS R35 GM138167NIGMS NIH HHS T32 GM007388
Abstract
Prime editing enables the precise modification of genomes through reverse transcription of template sequences appended to the 3' ends of CRISPR-Cas guide RNAs
Indexed as
Gene EditingRNA-Binding ProteinsAutoantigensCRISPR-Cas SystemsHumansK562 CellsPeptide FragmentsPoly URNA, Guide, CRISPR-Cas SystemsRNA Polymerase IIIAutoantigensPeptide FragmentsPoly URNA-Binding ProteinsRNA, Guide, CRISPR-Cas SystemsRNA Polymerase IIISSB protein, human
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.