Evidence map›Paper›PMID 38570678›Full record

ArticleNature2024

Immune microniches shape intestinal T

Yisu Gu, Raquel Bartolomé-Casado, Chuan Xu, Alice Bertocchi, Alina Janney, Cornelia Heuberger, Claire F Pearson, Sarah A Teichmann, Emily E Thornton, Fiona Powrie

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07626606 (Temporal and Spatial Immune Profiling of Oral Rotavirus Vaccine Responses in Zambian Adults With Environmental Enteropathy), which is not on this map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07626606 recruitingnot on this mapstarted 2026, after this paper: background citation

Temporal and Spatial Immune Profiling of Oral Rotavirus Vaccine Responses in Zambian Adults With Environmental Enteropathy

TypeobservationalSponsorCentre for Infectious Disease Research in ZambiaRan2026 to 2026Enrolled43ConditionsFeasibility Study, Vaccine Immune Response, Rota Virus Gastroenteritis, TranscriptomicsArmsRotarix®,
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Regulatory CD8Nature immunology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. The gut-bone-inflammation axis: intestinal barrier disruption as a central driver of osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Review
  8. Article
  9. Cardiolipin preserves TNature metabolism · 2026
    Article
  10. Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Yisu Gu *Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK.
Raquel Bartolomé-Casado *Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-8966-9047
Chuan XuWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-6265-999X
Alice BertocchiKennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK.ORCID 0000-0003-0909-2434
Alina JanneyKennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK.ORCID 0000-0002-0024-2603
Cornelia HeubergerKennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK.
Claire F PearsonKennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK.ORCID 0000-0001-5816-1657
Sarah A TeichmannWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-6294-6366
Emily E ThorntonKennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK. Emily.thornton@ndm.ox.ac.uk.ORCID 0000-0002-0068-2502
Fiona PowrieKennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK. Fiona.powrie@kennedy.ox.ac.uk.ORCID 0000-0003-3312-5929
University of Oxford · GBOslo University Hospital · NORoche (Switzerland) · CHUniversity of Cambridge · GBWellcome Sanger Institute · GB

Funding

Medical Research Council MC_UU_00008/6Wellcome Trust
6 · The paper itself

Abstract

The intestinal immune system is highly adapted to maintaining tolerance to the commensal microbiota and self-antigens while defending against invading pathogens

Indexed as

Intestinal MucosaMucous MembraneT-Lymphocytes, RegulatoryAnimalsAntigens, CDDendritic CellsFemaleGene Expression ProfilingHelicobacter hepaticusHelicobacter InfectionsImmune ToleranceInflammationIntegrin alpha ChainsMacrophagesMaleMembrane Glycoproteinsalpha E integrinsAntigens, CDIntegrin alpha ChainsMembrane GlycoproteinsMRC1 protein, mouseReceptors, ImmunologicSirpa protein, mouse

Identifiers

PMID38570678
PMCPMC11041794
OpenAlexW4393853792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.