Evidence map›Paper›PMID 38570581›Full record

ArticleScientific reports2024

Genetic predisposition to childhood obesity does not influence the risk of developing skin cancer in adulthood.

Jay Keatley, Matthew H Law, Mathias Seviiri, Catherine M Olsen, Nirmala Pandeya, Jue-Sheng Ong, Stuart MacGregor, David C Whiteman, Jean Claude Dusingize

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jay KeatleyFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Matthew H LawFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Mathias SeviiriDepartments of Population Health and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Catherine M OlsenFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Nirmala PandeyaFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Jue-Sheng OngDepartments of Population Health and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Stuart MacGregorFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
David C WhitemanFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Jean Claude DusingizeDepartments of Population Health and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. dusingize@gmail.com.
The University of Queensland · AUQIMR Berghofer Medical Research Institute · AUQueensland University of Technology · AU

Funding

National Health and Medical Research Council APP1073898, APP1063061, APP1185416 and APP1155413National Health and Medical Research Council APP1154543
6 · The paper itself

Abstract

The relationship between body mass index (BMI) and melanoma and other skin cancers remains unclear. The objective of this study was to employ the Mendelian randomization (MR) approach to evaluate the effects of genetically predicted childhood adiposity on the risk of developing skin cancer later in life. Two-sample MR analyses were conducted using summary data from genome-wide association study (GWAS) meta-analyses of childhood BMI, melanoma, cutaneous squamous cell carcinoma (cSCC), and basal cell carcinoma (BCC). We used the inverse-variance-weighted (IVW) methods to obtain a pooled estimate across all genetic variants for childhood BMI. We performed multiple sensitivity analyses to evaluate the potential influence of various assumptions on our findings. We found no evidence that genetically predicted childhood BMI was associated with risks of developing melanoma, cSCC, or BCC in adulthood (OR, 95% CI: melanoma: 1.02 (0.93-1.13), cSCC 0.94 (0.79-1.11), BCC 0.97 (0.84-1.12)). Our findings do not support the conclusions from observational studies that childhood BMI is associated with increased risks of melanoma, cSCC, or BCC in adulthood. Intervening on childhood adiposity will not reduce the risk of common skin cancers later in life.

Indexed as

Basal Cell CarcinomaCarcinoma, Squamous CellMelanomaPediatric ObesitySkin NeoplasmsBody Mass IndexChildGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMendelian Randomization AnalysisPolymorphism, Single Nucleotide

Identifiers

PMID38570581
PMCPMC10991302
OpenAlexW4393851202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.