ArticleNature communications2024
A distal enhancer guides the negative selection of toxic glycoalkaloids during tomato domestication.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Genetic basis of alkaloid divergence in the Solanaceae.Plant molecular biology · 2026Article
- The environmentally responsive plant epigenome: insights from jasmonate signaling.The New phytologist · 2026Review
- Novel genome editing approaches to manipulate apical meristem activity for crop yield.Frontiers in plant science · 2026Review
- CHIP-seq and transcriptomics reveal a new role of circadian-regulated StBBX24 protein in potato reproduction.BMC plant biology · 2025Article
- Ripening-induced defence signalling in Botrytis cinerea-infected tomato fruits involves activation of ERF.F4 by a MYC2-NOR/RIN protein complex.Plant biotechnology journal · 2025Article
- Nanoselenium application improves post-harvest fruit quality and disease resistance in tomato.The Plant journal : for cell and molecular biology · 2025Article
- Molecular breeding of tomato: Advances and challenges.Journal of integrative plant biology · 2025Review
- Removal of toxic steroidal glycoalkaloids and bitterness in tomato is controlled by a complex epigenetic and genetic network.Science advances · 2025Article
- Tomato secondary metabolites as natural regulators ofFrontiers in plant science · 2025Review
- Potato steroidal glycoalkaloids: properties, biosynthesis, regulation and genetic manipulation.Molecular horticulture · 2024Review
- DNA regulatory element cooperation and competition in transcription.BMB reports · 2024Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Steroidal glycoalkaloids (SGAs) are major plant defense metabolites against pests, while they are considered poisonous in food. The genetic basis that guides negative selection of SGAs production during tomato domestication remains poorly understood. Here, we identify a distal enhancer, GAME Enhancer 1 (GE1), as the key regulator of SGAs metabolism in tomato. GE1 recruits MYC2-GAME9 transcriptional complex to regulate the expression of GAME cluster genes via the formation of chromatin loops located in the neighboring DNA region. A naturally occurring GE1
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