Evidence map›Paper›PMID 38570478›Full record

ArticleNature communications2024

A modular organic neuromorphic spiking circuit for retina-inspired sensory coding and neurotransmitter-mediated neural pathways.

Giovanni Maria Matrone, Eveline R W van Doremaele, Abhijith Surendran, Zachary Laswick, Sophie Griggs, Gang Ye, Iain McCulloch, Francesca Santoro, Jonathan Rivnay, Yoeri van de Burgt

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
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  6. An organic artificial cardiomyocyte.Nature communications · 2026
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  18. Brain-Inspired Polymer Dendrite Networks for Morphology-Dependent Computing Hardware.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 8 countries.

Giovanni Maria Matrone *Microsystems, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5612AJ, Eindhoven, The Netherlands. giovanni.matrone@northwestern.edu.ORCID http://orcid.org/0000-0002-1496-2425
Eveline R W van Doremaele *Microsystems, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5612AJ, Eindhoven, The Netherlands.ORCID http://orcid.org/0000-0001-9812-7680
Abhijith SurendranDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.ORCID http://orcid.org/0009-0005-0477-0170
Zachary LaswickDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.
Sophie GriggsDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK.
Gang YeCenter for Biomedical Optics and Photonics (CBOP) & College of Physics and Optoelectronic Engineering, Key Laboratory of Optoelectronic Devices and Systems, Shenzhen University, Shenzhen, 518060, PR China.
Iain McCullochDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK.ORCID http://orcid.org/0000-0002-6340-7217
Francesca SantoroTissue Electronics, Istituto Italiano di Tecnologia, Naples, 80125, Italy.
Jonathan RivnayDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.ORCID http://orcid.org/0000-0002-0602-6485
Yoeri van de BurgtMicrosystems, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5612AJ, Eindhoven, The Netherlands. Y.B.v.d.Burgt@tue.nl.ORCID http://orcid.org/0000-0003-3472-0148
Northwestern University · USEindhoven University of Technology · NLUniversity of Oxford · GBForschungszentrum Jülich · DEShenzhen University · CN

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 802615
6 · The paper itself

Abstract

Signal communication mechanisms within the human body rely on the transmission and modulation of action potentials. Replicating the interdependent functions of receptors, neurons and synapses with organic artificial neurons and biohybrid synapses is an essential first step towards merging neuromorphic circuits and biological systems, crucial for computing at the biological interface. However, most organic neuromorphic systems are based on simple circuits which exhibit limited adaptability to both external and internal biological cues, and are restricted to emulate only specific the functions of an individual neuron/synapse. Here, we present a modular neuromorphic system which combines organic spiking neurons and biohybrid synapses to replicate a neural pathway. The spiking neuron mimics the sensory coding function of afferent neurons from light stimuli, while the neuromodulatory activity of interneurons is emulated by neurotransmitters-mediated biohybrid synapses. Combining these functions, we create a modular connection between multiple neurons to establish a pre-processing retinal pathway primitive.

Indexed as

InterneuronsNeuronsAction PotentialsHumansNeurons, AfferentNeurotransmitter AgentsSynapsesNeurotransmitter Agents

Identifiers

PMID38570478
PMCPMC10991258
OpenAlexW4393856115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.