Evidence map›Paper›PMID 38570460›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2024

Biophysical Characterization of RAS-SOS Complexes by Native Mass Spectrometry.

Sangho Yun, Elena Scott, Arthur Laganowsky

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sangho YunDepartment of Chemistry, Texas A&M University, College Station, TX, USA.
Elena ScottDepartment of Chemistry, Texas A&M University, College Station, TX, USA.
Arthur LaganowskyDepartment of Chemistry, Texas A&M University, College Station, TX, USA. ALaganowsky@chem.tamu.edu.
Texas A&M University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RAS is regulated by specific guanine nucleotide exchange factors, such as Son of Sevenless (SOS), that activates RAS by facilitating the exchange of inactive, GDP-bound RAS with GTP. The catalytic activity of SOS is known to be allosterically modulated by an active, GTP-bound RAS. However, it remains poorly understood how oncogenic RAS mutants interact with SOS and modulate its activity. In this chapter, we describe the application of native mass spectrometry (MS) to monitor the assembly of the catalytic domain of SOS (SOS

Indexed as

NucleotidesProto-Oncogene Proteins p21(ras)Catalytic DomainGuanine Nucleotide Exchange FactorsGuanosine TriphosphateGuanine Nucleotide Exchange FactorsGuanosine TriphosphateNucleotidesProto-Oncogene Proteins p21(ras)AllosteryDrugsKRASNative mass spectrometryRAS-SOS

Identifiers

PMID38570460
OpenAlexW4393870180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.