Evidence map›Paper›PMID 38570361›Full record

ReviewJournal of neural transmission (Vienna, Austria : 1996)2024

Unveiling the link between chronic pain and misuse of opioids and cannabis.

Merel Dagher, Myra Alayoubi, Gabriella H Sigal, Catherine M Cahill

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neural transmission (Vienna, Austria : 1996), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Merel DagherMacDonald Research Laboratory Building, Department of Psychiatry and Biobehavioral Sciences, Shirley and Stefan Hatos Center for Neuropharmacology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, 675 Charles E Young Drive South, Office 2774, Los Angeles, CA, 90095, USA.ORCID 0000-0003-0325-4543
Myra AlayoubiMacDonald Research Laboratory Building, Department of Psychiatry and Biobehavioral Sciences, Shirley and Stefan Hatos Center for Neuropharmacology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, 675 Charles E Young Drive South, Office 2774, Los Angeles, CA, 90095, USA.ORCID 0000-0003-0225-1316
Gabriella H SigalDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0009-0009-7215-9364
Catherine M CahillMacDonald Research Laboratory Building, Department of Psychiatry and Biobehavioral Sciences, Shirley and Stefan Hatos Center for Neuropharmacology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, 675 Charles E Young Drive South, Office 2774, Los Angeles, CA, 90095, USA. cmcahill@ucla.edu.ORCID 0000-0001-6936-5524
University of California, Los Angeles · US

Funding

UPLIFT: UCLA Postdocs' Longitudinal Investment in Faculty TrainingK12GM106996 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAREY, MICHAEL F, VILLANUEVA, CLAUDIO J · 2016 to 2025
$7.1M
Amygdala kappa opioid system involvement in opioid relapse in pain statesR01DA053752 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CATHERINE M CAHILL · 2022 to 2026
$2.8M
NIDA NIH HHS 5R01DA053752NIDA NIH HHS R01 DA053752NIGMS NIH HHS 2K12GM106996
6 · The paper itself

Abstract

Over 50 million Americans endure chronic pain where many do not receive adequate treatment and self-medicate to manage their pain by taking substances like opioids and cannabis. Research has shown high comorbidity between chronic pain and substance use disorders (SUD) and these disorders share many common neurobiological underpinnings, including hypodopaminergic transmission. Drugs commonly used for self-medication such as opioids and cannabis relieve emotional, bothersome components of pain as well as negative emotional affect that perpetuates misuse and increases the risk of progressing towards drug abuse. However, the causal effect between chronic pain and the development of SUDs has not been clearly established. In this review, we discuss evidence that affirms the proposition that chronic pain is a risk factor for the development of opioid and cannabis use disorders by outlining the clinical evidence and detailing neurobiological mechanisms that link pain and drug misuse. Central to the link between chronic pain and opioid and cannabis misuse is hypodopaminergic transmission and the modulation of dopamine signaling in the mesolimbic pathway by opioids and cannabis. Moreover, we discuss the role of kappa opioid receptor activation and neuroinflammation in the context of dopamine transmission, their contribution to opioid and cannabis withdrawal, along with potential new treatments.

Indexed as

Analgesics, OpioidChronic PainOpioid-Related DisordersAnimalsHumansMarijuana AbuseAnalgesics, OpioidAnxietyCannabinoidCannabisChronic painDepressionDopamineHypodopaminergic stateKappa opioid receptorsMarijuanaMood disorderNeuroinflammationNeuropathic painOpiateOpioidRisk factor

Identifiers

PMID38570361
OpenAlexW4393860787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.