Evidence map›Paper›PMID 38570359›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

Optimizing the pharmacokinetics of an

Hiroaki Echigo, Masayuki Munekane, Takeshi Fuchigami, Kohshin Washiyama, Kenji Mishiro, Hiroshi Wakabayashi, Kazuhiro Takahashi, Seigo Kinuya, Kazuma Ogawa

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Combination therapy of anEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Review
  5. Theranostic Application of Radiohalogens in Nuclear Medicine.Nuclear medicine and molecular imaging · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hiroaki EchigoGraduate School of Medical Sciences, Kanazawa University, Kakuma-Machi, Kanazawa, 920-1192, Ishikawa, Japan.
Masayuki MunekaneGraduate School of Medical Sciences, Kanazawa University, Kakuma-Machi, Kanazawa, 920-1192, Ishikawa, Japan.
Takeshi FuchigamiGraduate School of Medical Sciences, Kanazawa University, Kakuma-Machi, Kanazawa, 920-1192, Ishikawa, Japan.
Kohshin WashiyamaAdvanced Clinical Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Kenji MishiroInstitute for Frontier Science Initiative, Kanazawa University, Kakuma-Machi, Kanazawa, 920-1192, Ishikawa, Japan.
Hiroshi WakabayashiDepartment of Nuclear Medicine, Kanazawa University Hospital, Kanazawa University, Takara-Machi 13-1, Kanazawa, 920-8641, Ishikawa, Japan.
Kazuhiro TakahashiAdvanced Clinical Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Seigo KinuyaDepartment of Nuclear Medicine, Kanazawa University Hospital, Kanazawa University, Takara-Machi 13-1, Kanazawa, 920-8641, Ishikawa, Japan.
Kazuma OgawaGraduate School of Medical Sciences, Kanazawa University, Kakuma-Machi, Kanazawa, 920-1192, Ishikawa, Japan. kogawa@p.kanazawa-u.ac.jp.ORCID 0000-0002-1691-7302
Kanazawa University · JPFukushima Medical University · JPKanazawa University Hospital · JP

Funding

Japan Society for the Promotion of Science 21H02867
6 · The paper itself

Abstract

purposeA probe for targeted alpha therapy (TAT) using the RGD peptide (Ga-DOTA-K([

methodsTo evaluate the effects of albumin-binding inhibitors in normal mice, sodium 4-(4-iodophenyl)butanoate at 2, 5, or 10 molar equivalents of blood albumin was administered at 1-h postinjection of [

resultsBlood radioactivity of [

conclusionIPBA administration (as an albumin-binding inhibitor) could modulate the pharmacokinetics and enhance the therapeutic effects of [

Indexed as

OligopeptidesAlbuminsAnimalsCell Line, TumorFemaleHumansIsotope LabelingMaleMiceProtein BindingRadiopharmaceuticalsSerum AlbuminSingle Photon Emission Computed Tomography Computed TomographyTissue DistributionAlbuminsarginyl-glycyl-aspartic acidOligopeptidesRadiopharmaceuticalsSerum AlbuminAlbumin-binding moiety (ABM)Astatine-211RadiotheranosticsRGD peptideTargeted alpha therapy (TAT)

Identifiers

PMID38570359
PMCPMC11224111
OpenAlexW4394766778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.