Evidence map›Paper›PMID 38569877›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2024

Peripheral hearing loss at age 70 predicts brain atrophy and associated cognitive change.

Thomas D Parker, Chris Hardy, Sarah Keuss, William Coath, David M Cash, Kirsty Lu, Jennifer M Nicholas, Sarah-Naomi James, Carole Sudre, Sebastian Crutch and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Thomas D ParkerDepartment of Brain Sciences, Imperial College London, London, UK.ORCID 0000-0001-7679-4220
Chris HardyThe Dementia Research Centre, Department of Neurodegenerative Disease, University College London, London, UK.
Sarah KeussThe Dementia Research Centre, Department of Neurodegenerative Disease, University College London, London, UK.ORCID 0000-0002-7403-281X
William CoathThe Dementia Research Centre, Department of Neurodegenerative Disease, University College London, London, UK.
David M CashThe Dementia Research Centre, Department of Neurodegenerative Disease, University College London, London, UK.
Kirsty LuThe Dementia Research Centre, Department of Neurodegenerative Disease, University College London, London, UK.ORCID 0000-0002-8416-2183
Jennifer M NicholasThe Dementia Research Centre, Department of Neurodegenerative Disease, University College London, London, UK.
Sarah-Naomi JamesMRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Carole SudreThe Dementia Research Centre, Department of Neurodegenerative Disease, University College London, London, UK.
Sebastian CrutchThe Dementia Research Centre, Department of Neurodegenerative Disease, University College London, London, UK.
Doris-Eva BamiouUCL Ear Institute and UCLH Biomedical Research Centre, National Institute for Health Research, University College London, London, UK.
Jason D WarrenThe Dementia Research Centre, Department of Neurodegenerative Disease, University College London, London, UK.ORCID 0000-0002-5405-0826
Nick C FoxThe Dementia Research Centre, Department of Neurodegenerative Disease, University College London, London, UK.
Marcus RichardsMRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Jonathan M SchottThe Dementia Research Centre, Department of Neurodegenerative Disease, University College London, London, UK j.schott@ucl.ac.uk.ORCID 0000-0003-2059-024X
UK Dementia Research Institute · GBMRC Unit for Lifelong Health and Ageing · GBKing's College London · GBLondon School of Hygiene & Tropical Medicine · GBNational Institute for Health Research · GB

Funding

British Heart Foundation PG/17/90/33415Medical Research Council CSUB19166Medical Research Council MC-UU-12019/1Medical Research Council MC-UU-12019/3Wellcome Trust 200109/Z/15/Z TP
6 · The paper itself

Abstract

backgroundHearing loss has been proposed as a modifiable risk factor for dementia. However, the relationship between hearing, neurodegeneration, and cognitive change, and the extent to which pathological processes such as Alzheimer's disease and cerebrovascular disease influence these relationships, is unclear.

methodsData from 287 adults born in the same week of 1946 who underwent baseline pure tone audiometry (mean age=70.6 years) and two time point cognitive assessment/multimodal brain imaging (mean interval 2.4 years) were analysed. Hearing impairment at baseline was defined as a pure tone average of greater than 25 decibels in the best hearing ear. Rates of change for whole brain, hippocampal and ventricle volume were estimated from structural MRI using the Boundary Shift Integral. Cognition was assessed using the Pre-clinical Alzheimer's Cognitive Composite. Regression models were performed to evaluate how baseline hearing impairment associated with subsequent brain atrophy and cognitive decline after adjustment for a range of confounders including baseline β-amyloid deposition and white matter hyperintensity volume.

results111 out of 287 participants had hearing impairment. Compared with those with preserved hearing, hearing impaired individuals had faster rates of whole brain atrophy, and worse hearing (higher pure tone average) predicted faster rates of hippocampal atrophy. In participants with hearing impairment, faster rates of whole brain atrophy predicted greater cognitive change. All observed relationships were independent of β-amyloid deposition and white matter hyperintensity volume.

conclusionsHearing loss may influence dementia risk via pathways distinct from those typically implicated in Alzheimer's and cerebrovascular disease in cognitively unimpaired older adults.

Indexed as

AtrophyBrainCognitive DysfunctionHearing LossMagnetic Resonance ImagingAgedAudiometry, Pure-ToneFemaleHippocampusHumansMaleALZHEIMER'S DISEASEAMYLOIDCEREBROVASCULAR DISEASECOGNITIVE NEUROPSYCHOLOGYDEMENTIA

Identifiers

PMID38569877
PMCPMC11347269
OpenAlexW4393902715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.