Evidence map›Paper›PMID 38569543›Full record

ArticleCell2024

Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria.

Chenhao Li, Martin Stražar, Ahmed M T Mohamed, Julian A Pacheco, Rebecca L Walker, Tina Lebar, Shijie Zhao, Julia Lockart, Andrea Dame, Kumar Thurimella and 16 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 1 pooled it
44.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 1 synthesis or guideline pooled it, 191 citations in OpenAlex.

  1. Berberine and health outcomes: an overview of systematic reviews.BMC complementary medicine and therapies · 2025
    Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. A novel exopolysaccharide fromGut microbes · 2026
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The gut-heart axis in cardio-oncology.Cardiovascular research · 2026
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 4 institutions in 1 country.

Chenhao LiBroad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Martin StražarBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Ahmed M T MohamedBroad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Julian A PachecoBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Rebecca L WalkerBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Tina LebarWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
Shijie ZhaoBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Julia LockartBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Andrea DameBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Kumar ThurimellaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sarah JeanfavreBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Eric M BrownBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Qi Yan AngBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Brittany BerdyBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Dallis SergioBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Rachele InvernizziBroad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Antonio TinocoDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Gleb PishchanyBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Ramachandran S VasanBoston University and NHLBI's Framingham Heart Study, Framingham, MA, USA; Sections of Preventive Medicine and Epidemiology and Cardiology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA; University of Texas School of Public Health, San Antonio, TX, USA.
Emily BalskusDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.
Curtis HuttenhowerBroad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Hera VlamakisBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Clary ClishBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Stanley Y ShawBroad Institute of MIT and Harvard, Cambridge, MA, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Damian R PlichtaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Ramnik J XavierBroad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: xavier@molbio.mgh.harvard.edu.
Broad Institute · USHarvard University · USBoston University · USHoward Hughes Medical Institute · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Cardiovascular disease, metabolic syndrome, microbes and metabolites in FHSR01HL157717 · NHLBI · BROAD INSTITUTE, INC. · PI XAVIER, RAMNIK J · 2022 to 2025
$3.9M
NHLBI NIH HHS R01 HL157717NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK043351
6 · The paper itself

Abstract

Accumulating evidence suggests that cardiovascular disease (CVD) is associated with an altered gut microbiome. Our understanding of the underlying mechanisms has been hindered by lack of matched multi-omic data with diagnostic biomarkers. To comprehensively profile gut microbiome contributions to CVD, we generated stool metagenomics and metabolomics from 1,429 Framingham Heart Study participants. We identified blood lipids and cardiovascular health measurements associated with microbiome and metabolome composition. Integrated analysis revealed microbial pathways implicated in CVD, including flavonoid, γ-butyrobetaine, and cholesterol metabolism. Species from the Oscillibacter genus were associated with decreased fecal and plasma cholesterol levels. Using functional prediction and in vitro characterization of multiple representative human gut Oscillibacter isolates, we uncovered conserved cholesterol-metabolizing capabilities, including glycosylation and dehydrogenation. These findings suggest that cholesterol metabolism is a broad property of phylogenetically diverse Oscillibacter spp., with potential benefits for lipid homeostasis and cardiovascular health.

Indexed as

BacteriaCardiovascular DiseasesCholesterolGastrointestinal MicrobiomeFecesHumansLongitudinal StudiesMetabolomeMetabolomicsRNA, Ribosomal, 16SCholesterolRNA, Ribosomal, 16SCardiovascular diseaseCholesterolMetabolomeMicrobiomeOscillibacter

Identifiers

PMID38569543
PMCPMC11071153
OpenAlexW4393411172

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.