Evidence map›Paper›PMID 38569318›Full record

ArticleEBioMedicine2024

CHRFAM7A diversifies human immune adaption through Ca

Kinga Szigeti, Ivanna Ihnatovych, Emily Notari, Ryu P Dorn, Ivan Maly, Muye He, Barbara Birkaya, Shreyas Prasad, Robin Schwartz Byrne, Dinesh C Indurthi and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Kinga SzigetiState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA. Electronic address: szigeti@buffalo.edu.
Ivanna IhnatovychState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Emily NotariState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Ryu P DornState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Ivan MalyState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Muye HeState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Barbara BirkayaState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Shreyas PrasadState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Robin Schwartz ByrneState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Dinesh C IndurthiState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Erik NimmerState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Yuna HeoState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Kolos RetfalviState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Lee ChavesState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Norbert SuleRoswell Park Comprehensive Cancer Center, 665 Elm St, Buffalo, NY, 14203, USA.
Wilma A HofmannState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Anthony AuerbachState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Gregory WildingState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Yongho BaeState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
Jessica ReynoldsState University of New York at Buffalo, 875 Ellicott St., Buffalo, NY, 14203, USA.
University at Buffalo, State University of New York · USBuffalo State University · USRoswell Park Comprehensive Cancer Center · US

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Biomimetic Vascular Matrix for Vascular Smooth Muscle Cell Mechanobiology and PathologyR01HL163168 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Yongho Bae, Su Chin Heo · 2023 to 2026
$2.2M
NCATS NIH HHS UL1 TR001412NHLBI NIH HHS R01 HL163168
6 · The paper itself

Abstract

backgroundHuman restricted genes contribute to human specific traits in the immune system. CHRFAM7A, a uniquely human fusion gene, is a negative regulator of the α7 nicotinic acetylcholine receptor (α7 nAChR), the highest Ca

methodsTwo model systems are used, human induced pluripotent stem cells (iPSC) and human primary monocytes, to characterize α7 nAChR function, Ca

findingsCHRFAM7A/α7 nAChR is identified as a hypomorphic receptor with mitigated Ca

interpretationCHRFAM7A introduces an additional, human specific, layer to Ca

fundingThis work is supported in part by the Community Foundation for Greater Buffalo (Kinga Szigeti) and in part by NIH grant R01HL163168 (Yongho Bae).

Indexed as

Actin Cytoskeletonalpha7 Nicotinic Acetylcholine ReceptorCalcium SignalingInduced Pluripotent Stem CellsCalciumHumansImmunity, InnateMonocytesPhagocytosisrac1 GTP-Binding Proteinalpha7 Nicotinic Acetylcholine ReceptorCalciumChrna7 protein, humanrac1 GTP-Binding ProteinActin cytoskeletonAdaptation to the mechanical propertiesCa(2+) signallingCHRFAM7AHuman immune diversityTranslational significance

Identifiers

PMID38569318
PMCPMC10999709
OpenAlexW4393678242

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.