Evidence map›Paper›PMID 38569195›Full record

ReviewAnnals of medicine2024

A brief review of complex regional pain syndrome and current management.

Alaa Abd-Elsayed, Cain W Stark, Natasha Topoluk, Mir Isaamullah, Paul Uzodinma, Omar Viswanath, Michael J Gyorfi, Osama Fattouh, Kevin C Schlidt, Omar Dyara

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
19.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Alaa Abd-ElsayedDepartment of Anesthesiology, University of WI School of Medicine and Public Health, Madison, WI, USA.
Cain W StarkDepartment of Anesthesiology, Medical College of Wisconsin, Wauwatosa, WI, USA.
Natasha TopolukDepartment of Anesthesiology, Medical College of Wisconsin, Wauwatosa, WI, USA.
Mir IsaamullahDepartment of Anesthesiology, Medical College of Wisconsin, Wauwatosa, WI, USA.
Paul UzodinmaDepartment of Anesthesiology, Medical College of Wisconsin, Wauwatosa, WI, USA.
Omar ViswanathAnesthesiology, LSU Health Sciences Center School of Medicine, New Orleans, LA, USA.
Michael J GyorfiDepartment of Anesthesiology, University of WI School of Medicine and Public Health, Madison, WI, USA.
Osama FattouhDepartment of Neurobiology, University of Wisconsin-Madison, Madison, WI, USA.
Kevin C SchlidtDepartment of Surgery, Sinai Hospital of Baltimore, Baltimore, MD, USA.
Omar DyaraDepartment of Anesthesiology, Medical College of Wisconsin, Wauwatosa, WI, USA.
Medical College of Wisconsin · USUniversity of Wisconsin–Madison · USLouisiana State University Health Sciences Center New Orleans · USSinai Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complex regional pain syndrome (CRPS) is a debilitating chronic pain condition that, although exceedingly rare, carries a significant burden for the affected patient population. The complex and ambiguous pathophysiology of this condition further complicates clinical management and therapeutic interventions. Furthermore, being a diagnosis of exclusion requires a diligent workup to ensure an accurate diagnosis and subsequent targeted management. The development of the Budapest diagnostic criteria helped to consolidate existing definitions of CRPS but extensive work remains in identifying the underlying pathways. Currently, two distinct types are identified by the presence (CRPS type 1) or absence (CRPS type 2) of neuronal injury. Current management directed at this disease is broad and growing, ranging from non-invasive modalities such as physical and psychological therapy to more invasive techniques such as dorsal root ganglion stimulation and potentially amputation. Ideal therapeutic interventions are multimodal in nature to address the likely multifactorial pathological development of CRPS. Regardless, a significant need remains for continued studies to elucidate the pathways involved in developing CRPS as well as more robust clinical trials for various treatment modalities.

Indexed as

Chronic PainComplex Regional Pain SyndromesHumansPain MeasurementamputationantioxidantsBotulinum toxin ABudapest criteriaComplex regional pain syndromedorsal root ganglion stimulationgabapentinketaminespinal cord stimulationsympathetic blocks

Identifiers

PMID38569195
PMCPMC10993759
OpenAlexW4393860082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.