Evidence map›Paper›PMID 38569033›Full record

ArticleScience advances2024

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

Guy J Pearson, Harriet V Mears, Malgorzata Broncel, Ambrosius P Snijders, David L V Bauer, Jeremy G Carlton

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  9. Case Study: Illuminating the Nanoscale World of Microbiology.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Nonlytic Egress and Transmission in the Virus World.Annual review of biochemistry · 2025
    Review
  14. Perturbation ofJournal of virology · 2025
    Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Guy J PearsonOrganelle Dynamics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0001-8623-9239
Harriet V MearsRNA Virus Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0003-0300-0885
Malgorzata BroncelProteomic Science Technology Platform, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0003-2991-3500
Ambrosius P SnijdersProteomic Science Technology Platform, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
David L V BauerRNA Virus Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0003-3052-0368
Jeremy G CarltonOrganelle Dynamics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0002-7255-1894
The Francis Crick Institute · GBKing's College London · GB

Funding

Wellcome Trust CC2166
6 · The paper itself

Abstract

The β-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the global COVID-19 pandemic. Coronaviral Envelope (E) proteins are pentameric viroporins that play essential roles in assembly, release, and pathogenesis. We developed a nondisruptive tagging strategy for SARS-CoV-2 E and find that, at steady state, it localizes to the Golgi and to lysosomes. We identify sequences in E, conserved across

Indexed as

COVID-19SARS-CoV-2ADP-Ribosylation FactorsHumansLysosomesPandemicsTranscription Factor AP-1Viral Envelope ProteinsVirus ReplicationADP-Ribosylation FactorsARFRP1 protein, humanTranscription Factor AP-1Viral Envelope Proteins

Identifiers

PMID38569033
PMCPMC10990277
OpenAlexW4393863164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.