ArticleCell reports2024
Stereotyped goal-directed manifold dynamics in the insular cortex.
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Insular cortex predictions regulate glucose homeostasis.bioRxiv : the preprint server for biology · 2025Article
- Dissociable cortical contributions to impulse control during waiting.Science advances · 2025Article
- Article
- A neural manifold view of the brain.Nature neuroscience · 2025Review
- Neuronal Sequences and dynamic coding of water-sucrose categorization in rat gustatory cortices.iScience · 2024Article
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Authors and funding
2 authors.
Funding
Abstract
The insular cortex is involved in diverse processes, including bodily homeostasis, emotions, and cognition. However, we lack a comprehensive understanding of how it processes information at the level of neuronal populations. We leveraged recent advances in unsupervised machine learning to study insular cortex population activity patterns (i.e., neuronal manifold) in mice performing goal-directed behaviors. We find that the insular cortex activity manifold is remarkably consistent across different animals and under different motivational states. Activity dynamics within the neuronal manifold are highly stereotyped during rewarded trials, enabling robust prediction of single-trial outcomes across different mice and across various natural and artificial motivational states. Comparing goal-directed behavior with self-paced free consumption, we find that the stereotyped activity patterns reflect task-dependent goal-directed reward anticipation, and not licking, taste, or positive valence. These findings reveal a core computation in insular cortex that could explain its involvement in pathologies involving aberrant motivations.
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