Evidence map›Paper›PMID 38568782›Full record

ArticleMolecular biology of the cell2024

The MBO2/FAP58 heterodimer stabilizes assembly of inner arm dynein

Gang Fu, Katherine Augspurger, Jason Sakizadeh, Jaimee Reck, Raqual Bower, Douglas Tritschler, Long Gui, Daniela Nicastro, Mary E Porter

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Gang FuDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-5174-7011
Katherine AugspurgerDepartment of Genetics, Cell Biology, and Genetics, University of Minnesota, Minneapolis, MN 55455.
Jason SakizadehDepartment of Genetics, Cell Biology, and Genetics, University of Minnesota, Minneapolis, MN 55455.
Jaimee ReckDepartment of Genetics, Cell Biology, and Genetics, University of Minnesota, Minneapolis, MN 55455.
Raqual BowerDepartment of Genetics, Cell Biology, and Genetics, University of Minnesota, Minneapolis, MN 55455.
Douglas TritschlerDepartment of Genetics, Cell Biology, and Genetics, University of Minnesota, Minneapolis, MN 55455.
Long GuiDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Daniela NicastroDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-0122-7173
Mary E PorterDepartment of Genetics, Cell Biology, and Genetics, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0001-8682-7655
University of Minnesota · USThe University of Texas Southwestern Medical Center · US

Funding

Structure and Function of Complexes that Regulate Ciliary MotilityR01GM083122 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Daniela Nicastro · 2007 to 2026
$6.2M
Assembly, Targeting, And Regulation Of Dynein MotorsR01GM055667 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI PORTER, MARY E. · 1997 to 2023
$5.4M
Assembly , Targeting, and Regulation of Dynein MotorsR37GM055667 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI PORTER, MARY E. · 2005 to 2014
$4.0M
NIGMS NIH HHS R01 GM055667NIGMS NIH HHS R01 GM083122NIGMS NIH HHS R37 GM055667
6 · The paper itself

Abstract

Cilia generate three-dimensional waveforms required for cell motility and transport of fluid, mucus, and particles over the cell surface. This movement is driven by multiple dynein motors attached to nine outer doublet microtubules that form the axoneme. The outer and inner arm dyneins are organized into 96-nm repeats tandemly arrayed along the length of the doublets. Motility is regulated in part by projections from the two central pair microtubules that contact radial spokes located near the base of the inner dynein arms in each repeat. Although much is known about the structures and protein complexes within the axoneme, many questions remain about the regulatory mechanisms that allow the cilia to modify their waveforms in response to internal or external stimuli. Here, we used

Indexed as

AxonemeDyneinsCiliaFlagellaMicrotubulesProteinsDyneinsProteins

Identifiers

PMID38568782
PMCPMC11151096
OpenAlexW4393870065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.