ArticleEndocrine2024
NIFTP-adjusted risk estimation of Bethesda thyroid cytology categories should consider the indication for FNA according to TIRADS.
Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Clinical, ultrasonographic, and cytological characteristics of niftp and postoperative outcomes: a retrospective cohort study.Endocrine · 2026Article
- Clinical management of indeterminate thyroid nodules needs to be revisited. New evidence for a personalized approach to the problem.Journal of endocrinological investigation · 2025Observational
- Impact of ultrasound elastography in evaluating Bethesda category IV thyroid nodules with histopathological correlation.Frontiers in endocrinology · 2024Article
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9 authors.
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Abstract
backgroundNon-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was firstly described in 2016. Since NIFTP is thought a non-malignant tumor, the Bethesda system for thyroid cytology proposes two estimations of risk of malignancy of the diagnostic categories, one considering NIFTP as cancer and another one considering it as a benign neoplasm. The present study aimed to review NIFTPs in a single center, re-assess them across categories of three Thyroid Imaging Reporting and Data Systems (TIRADSs), and define the indication for biopsy according to the category-specific size cut-offs.
methodsThe study period was from 2017 to 2023. The institutional database was searched for histologically proven NIFTPs with preoperative ultrasound images. NIFTPs were re-assessed according to the American College of Radiology (ACR), European (EU), and Korean (K) TIRADSs. The indication for biopsy was defined according to TIRADS category-specific size threshold.
resultsTwenty NIFTPs from 19 patients were included. The median size of the NIFTPs was 23 mm. According to ultrasound, 80-85% of NIFTPs were at low-intermediate risk and 5-15% at high risk without significant difference among the tree TIRADSs (p = 0.91). The indication for FNA, according to three TIRADSs, was found in 52-58% of cases with no significant difference among systems (p = 0.96).
conclusionNIFTPs have heterogeneous presentation according to TIRADSs with very low indication rate for FNA.
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