Evidence map›Paper›PMID 38568289›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2024

ent-8(14),15-Pimaradiene-2β,19-diol, a diterpene from Aleuritopteris albofusca, inhibits growth and induces protective autophagy in hepatocellular carcinoma cells.

Yumeng Zhang, Zi Liu, Fuchun Wang, Jian Liu, Yu Zhang, Jianguo Cao, Guozheng Huang, Liang Ma

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yumeng ZhangDepartment of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, Anhui, 243002, People's Republic of China.
Zi LiuDepartment of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, Anhui, 243002, People's Republic of China.
Fuchun WangDepartment of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, Anhui, 243002, People's Republic of China.
Jian LiuDepartment of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, Anhui, 243002, People's Republic of China.
Yu ZhangDepartment of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, Anhui, 243002, People's Republic of China.
Jianguo CaoDepartment of Biology, College of Life Sciences, Shanghai Normal University, Shanghai, 201418, People's Republic of China.
Guozheng HuangDepartment of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, Anhui, 243002, People's Republic of China. guozheng.huang@ahut.edu.cn.ORCID http://orcid.org/0000-0002-5730-9549
Liang MaDepartment of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, Anhui, 243002, People's Republic of China. mal2014@ahut.edu.cn.ORCID http://orcid.org/0000-0001-9131-4512
Anhui University of Technology · CNShanghai Normal University · CN

Funding

National Natural Science Foundation of China 81872449Natural Science Foundation of Anhui Province 2008085MH292the Key Program in the Youth Elite Support Plan in Universities of Anhui Province gxyqZD2019020the Key Program in the Youth Elite Support Plan in Universities of Anhui Province gxyqZD2020016the Student Research and Training Program of Anhui University of Technology S202210360211
6 · The paper itself

Abstract

A new pimarane-type diterpene, ent-8(14),15-pimaradiene-2β,19-diol (JXE-23), was isolated from the fern plant Aleuritopteris albofusca by our previous work; however, the biological activity of this diterpene remains unclear. In the present study, the anti-cancer potential of JXE-23 in various cancer cells was investigated. Among MCF-7 breast cancer cells, A549 lung cancer cells, and HepG2 liver cancer cells, JXE-23 displayed significant cytotoxicity to HepG2 cells with an IC

Indexed as

Antineoplastic Agents, PhytogenicAutophagyCarcinoma, HepatocellularCell ProliferationDiterpenesLiver NeoplasmsA549 CellsApoptosisCell SurvivalFernsHep G2 CellsHumansMCF-7 CellsAntineoplastic Agents, PhytogenicDiterpenesAutophagyCell cycleCIP2Aent-8(14),15-Pimaradiene-2β,19-diol (JXE-23)Hepatocellular carcinoma

Identifiers

PMID38568289
OpenAlexW4393864675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.