Evidence map›Paper›PMID 38568233›Full record

ArticleAnalytical and bioanalytical chemistry2024

Development and validation of a GC-MS/MS method for the determination of iodoacetic acid in biological samples.

Hanning Yu, Linying Wu, Dongliang Xuan, Qian Peng, Weidong Qu, Ying Zhou

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hanning YuCenters for Water and Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, 200032, China.
Linying WuJiading District Center for Disease Control and Prevention, Shanghai, 201899, China.
Dongliang XuanJiading District Center for Disease Control and Prevention, Shanghai, 201899, China.
Qian PengJiading District Center for Disease Control and Prevention, Shanghai, 201899, China.
Weidong QuCenters for Water and Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, 200032, China. wdqu@fudan.edu.cn.
Ying ZhouCenters for Water and Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, 200032, China. yingchou@fudan.edu.cn.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iodoacetic acid (IAA) is a halogenated disinfection by-product of growing concern due to its high cytotoxicity, genotoxicity, endocrine disruptor effects, and potential carcinogenicity. However, the data on distribution and excretion of IAA after ingestion by mammals are still scarce. Here, we developed a reliable and validated method for detecting IAA in biological specimens (plasma, urine, feces, liver, kidney, and tissues) based on modified QuEChERS sample preparation combined with gas chromatography-tandem triple quadrupole mass spectrometry (GC-MS/MS). The detection method for IAA exhibited satisfactory recovery rates (62.6-108.0%) with low relative standard deviations (RSD < 12.3%) and a low detection limit for all biological matrices ranging from 0.007 to 0.032 ng/g. The study showed that the proposed method was reliable and reproducible for analyzing IAA in biological specimens. It was successfully used to detect IAA levels in biological samples from rats given gavage administration. The results indicated that IAA was found in various tissues and organs, including plasma, thyroid, the liver, the kidney, the spleen, gastrointestinal tract, and others, 6 h after exposure. This study provides the first data on the in vivo distribution in and excretion of IAA by mammals following oral exposure.

Indexed as

Gas Chromatography-Mass SpectrometryIodoacetic AcidLimit of DetectionTandem Mass SpectrometryAnimalsFecesKidneyLiverMaleRatsRats, Sprague-DawleyReproducibility of ResultsTissue DistributionIodoacetic AcidBiological sampleDistribution and excretionGas chromatography-tandem triple quadrupole mass spectrometryIodoacetic acidQuEChERS

Identifiers

PMID38568233
OpenAlexW4393910663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.