Evidence map›Paper›PMID 38568226›Full record

ArticleJournal of neurology2024

Acute recanalization therapy for ischemic stroke during pregnancy and puerperium.

Anna Richardt, Karoliina Aarnio, Aino Korhonen, Kirsi Rantanen, Liisa Verho, Sami Curtze, Hannele Laivuori, Mika Gissler, Minna Tikkanen, Petra Ijäs

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Anna RichardtNeurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. anna.richardt@helsinki.fi.ORCID http://orcid.org/0000-0002-1739-3344
Karoliina AarnioNeurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Aino KorhonenNeurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Kirsi RantanenNeurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Liisa VerhoObstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Sami CurtzeNeurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Hannele LaivuoriMedical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Mika GisslerDepartment of Knowledge Brokers, Finnish Institute for Health and Welfare, Helsinki, Finland.
Minna TikkanenObstetrics and Gynecology, University of Helsinki, Helsinki, Finland.
Petra IjäsNeurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
University of Helsinki · FIKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe safety and efficacy of intravenous thrombolysis (IVT) and endovascular thrombectomy for an ischemic stroke (IS) during pregnancy and puerperium are poorly studied. We evaluated the complications and outcome of recanalization therapy in maternal ISs.

methodsA nationwide cohort of maternal ISs in Finland during 1987-2016 was collected by linking national healthcare registers: Medical Birth Register, Hospital Discharge Register, and Cause-Of-Death Register. The diagnoses were verified retrospectively from patient records. IVT-treated patients were compared to controls, who were young females with non-pregnancy-related IS from the Helsinki Stroke Thrombolysis Registry.

resultsTotally, 12 of 97 (12.4%) maternal ISs were treated with recanalization therapy. Compared to controls, IVT-treated maternal IS patients had more frequently early (age-adjusted odds ratio (aOR) = 7.63, 95% CI 1.49-39.04) and major (aOR = 8.59, 95% CI 2.09-35.31) neurological improvements, measured using the National Institute of Health Stroke Scale. Good functional outcomes (modified Rankin Scale 0-2) at three months were equally common in maternal ISs and controls. No other complications were observed in IVT-treated maternal ISs than 1 (9.1%) symptomatic nonfatal intracranial hemorrhage. Among maternal IS patients treated with recanalization or conventional therapy, good functional outcome at the end of the follow-up was less common in recanalization-treated patients (66.7% vs 89.4%, aOR = 0.22, 95% CI 0.052-0.90), but otherwise outcomes were similar.

conclusionsIn this small nationwide cohort of maternal ISs, the complications of recanalization therapy were rare, and the outcomes were similar in IVT-treated maternal IS patients and controls. Maternal ISs should not be excluded from recanalization therapy in otherwise eligible situations.

Indexed as

Ischemic StrokePostpartum PeriodThrombolytic TherapyAdultEndovascular ProceduresFemaleFibrinolytic AgentsFinlandHumansPregnancyPregnancy Complications, CardiovascularRegistriesRetrospective StudiesThrombectomyFibrinolytic AgentsEndovascular thrombectomyIntravenous thrombolysisIschemic strokePregnancyPuerperiumRecanalization therapy

Identifiers

PMID38568226
PMCPMC11233356
OpenAlexW4393864620

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.