Evidence map›Paper›PMID 38568076›Full record

ArticleApplied and environmental microbiology2024

pH-dependent regulation of an acidophilic

Yasuyuki Matoba, Kosuke Oda, Maho Wataeda, Hina Kanemori, Koichi Matsuo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yasuyuki MatobaFaculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan.ORCID 0000-0002-0366-0851
Kosuke OdaFaculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan.
Maho WataedaFaculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan.
Hina KanemoriFaculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan.
Koichi MatsuoHiroshima Synchrotron Radiation Center, Hiroshima University, Hiroshima, Japan.
Yasuda Women's University · JPHiroshima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteria have two routes for the l-methionine biosynthesis. In one route called the direct sulfuration pathway, acetylated l-homoserine is directly converted into l-homocysteine. The reaction using H IMPORTANCE: In the present study, we can elucidate the pH-dependent regulation mechanism of the acidophilic OAHS. The acidophilic feature of the enzyme is caused by the introduction of an acidic residue to the neighborhood of the key acidic residue acting as a switch for the structural interconversion. The strategy may be useful in the field of protein engineering to change the optimal pH of the enzymes. In addition, this study may be useful for the development of antibacterial drugs because the l-methionine synthesis essential for bacteria is inhibited by the OAHS inhibitors. The compounds that can inhibit the interconversion between the open and closed forms of OAHS may become antibacterial drugs.

Indexed as

Bacterial ProteinsLactiplantibacillus plantarumCarbon-Oxygen LyasesHydrogen-Ion ConcentrationBacterial ProteinsCarbon-Oxygen LyasesO-acetylhomoserine (thiol)-lyaseacidophilicityLactobacillus plantaruml-methionineO-acetylhomoserine sulfhydrylasepH-dependent regulation

Identifiers

PMID38568076
PMCPMC11107162
OpenAlexW4393898811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.