Evidence map›Paper›PMID 38567911›Full record

ArticleeLife2024

Water-soluble 4-(dimethylaminomethyl)heliomycin exerts greater antitumor effects than parental heliomycin by targeting the tNOX-SIRT1 axis and apoptosis in oral cancer cells.

Atikul Islam, Yu-Chun Chang, Xiao-Chi Chen, Chia-Wei Weng, Chien-Yu Chen, Che-Wei Wang, Mu-Kuan Chen, Alexander S Tikhomirov, Andrey E Shchekotikhin, Pin Ju Chueh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 4 countries.

Atikul IslamInstitute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.ORCID https://orcid.org/0009-0004-9575-5963
Yu-Chun ChangInstitute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
Xiao-Chi ChenInstitute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
Chia-Wei WengInstitute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.ORCID https://orcid.org/0000-0002-4842-7308
Chien-Yu ChenInstitute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
Che-Wei WangDepartment of Otorhinolaryngology-Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan.
Mu-Kuan ChenDepartment of Otorhinolaryngology-Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan.
Alexander S TikhomirovGause Institute of New Antibiotics, Moscow, Russian Federation.
Andrey E ShchekotikhinGause Institute of New Antibiotics, Moscow, Russian Federation.
Pin Ju ChuehInstitute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.ORCID https://orcid.org/0000-0002-3200-7552
National Chung Hsing University · TWGause Institute of New Antibiotics Russian Academy of Medical Sciences · RU

Funding

National Chung Hsing University and Changhua Christian Hospital NCHU-CCH 11105Russian Foundation for Basic Research Project 19-53-52008The Ministry of Sciences and Technology, Taiwan MOST 106-2320-B-005-008-MY3The Minsitry of Sciences and Technology, Taiwan MOST 108-2923-B-005-001-MY3
6 · The paper itself

Abstract

The antibiotic heliomycin (resistomycin), which is generated from

Indexed as

Mouth NeoplasmsPolycyclic CompoundsSirtuin 1AnimalsApoptosisCell Line, TumorHumansMiceMolecular Docking SimulationNADTumor Suppressor Protein p53heliomycinNADPolycyclic CompoundsSIRT1 protein, humanSirtuin 1Tumor Suppressor Protein p53apoptosisbiochemistrycancer biologychemical biologyenox2heliomycinhumanmouseoral cancer cellsresistomycinsirt1sirtuin 1tnoxtumor-associated nadh oxidase

Identifiers

PMID38567911
PMCPMC10990494
OpenAlexW4386167557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.