Evidence map›Paper›PMID 38567797›Full record

ArticleInternational journal of cancer2024

Time-specific impact of trace metals on breast density of adolescent girls in Santiago, Chile.

Claire E Kim, Ana Pereira, Alexandra M Binder, Chitra Amarasiriwardena, John A Shepherd, Camila Corvalan, Karin B Michels

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Environmental factors trigger pubertal development.Current opinion in pediatrics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Claire E KimDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA.ORCID 0000-0002-1163-8590
Ana PereiraInstitute of Nutrition and Food Technology, University of Chile, Santiago, Chile.
Alexandra M BinderDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA.
Chitra AmarasiriwardenaDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
John A ShepherdPopulation Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Camila CorvalanInstitute of Nutrition and Food Technology, University of Chile, Santiago, Chile.
Karin B MichelsDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA.
University of Chile · CLUniversity of Hawaiʻi at Mānoa · USIcahn School of Medicine at Mount Sinai · USUniversity of California, Los Angeles · USUniversity of Freiburg · DE

Funding

Untargeted Analysis ResourceU2CES026561 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WRIGHT, ROBERT O · 2015 to 2025
$24.5M
Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
UCLA CANCER EPIDEMIOLOGY TRAINING PROGRAMT32CA009142 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1986 to 2024
$6.3M
Environmental chemicals and postpubertal breast composition in a Latino cohortU01ES026130 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRODY, JULIA GREEN, CORVALAN, CAMILA · 2015 to 2019
$4.4M
National Cancer Institute, National Institutes of Health T32CA009001National Cancer Institute, National Institutes of Health T32CA009142National Institute of Environmental Health Sciences and National Cancer Institute, National Institutes of Health U01ES026130National Institute of Environmental Health Sciences and National Cancer Institute, National Institutes of Health U2CES026561NCI NIH HHS T32 CA009001NCI NIH HHS T32 CA009142NIEHS NIH HHS U01 ES026130NIEHS NIH HHS U2C ES026561
6 · The paper itself

Abstract

Whether trace metals modify breast density, the strongest predictor for breast cancer, during critical developmental stages such as puberty remains understudied. Our study prospectively evaluated the association between trace metals at Tanner breast stage B1 (n = 291) and at stages both B1 and B4 (n = 253) and breast density at 2 years post-menarche among Chilean girls from the Growth and Obesity Cohort Study. Dual-energy x-ray absorptiometry assessed the volume of dense breast tissue (absolute fibroglandular volume [FGV]) and percent breast density (%FGV). Urine trace metals included arsenic, barium, cadmium, cobalt, cesium, copper, magnesium, manganese, molybdenum, nickel, lead, antimony, selenium, tin, thallium, vanadium, and zinc. At B1, a doubling of thallium concentration resulted in 13.69 cm

Indexed as

Absorptiometry, PhotonBreast DensityTrace ElementsAdolescentBreastBreast NeoplasmsChildChileFemaleHumansProspective StudiesTrace Elementsbreast cancerbreast densitypubertytrace metals

Identifiers

PMID38567797
PMCPMC11186724
OpenAlexW4393902619

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.