Evidence map›Paper›PMID 38567377›Full record

ArticleForensic sciences research2024

Collaborative exercise: analysis of age estimation using a QIAGEN protocol and the PyroMark Q48 platform.

Marie-Louise Kampmann, Jan Fleckhaus, Claus Børsting, Helena Jurtikova, Alice Piters, Julien Papin, Quentin Gauthier, Mirna Ghemrawi, Christian Doutremepuich, Bruce McCord and 3 more

Abstract read
In one paragraph

Article in Forensic sciences research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. InvestigatingBrain sciences · 2025
    Article
  4. A Sex-Specific Minimal CpG-Based Model for Biological Aging UsingInternational journal of molecular sciences · 2025
    Article
  5. DNA Methylation ofBiomolecules · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marie-Louise KampmannSection of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of CopenhagenCopenhagen, Denmark.
Jan FleckhausInstitute of Legal Medicine, Faculty of Medicine and University Clinic, University of Cologne, Cologne, Germany.
Claus BørstingSection of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of CopenhagenCopenhagen, Denmark.
Helena JurtikovaInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and the University Hospital Olomouc, Olomouc, the Czech Republic.
Alice PitersLaboratoire d'Hématologie Médico-Légale, Bordeaux Cedex, France.
Julien PapinLaboratoire d'Hématologie Médico-Légale, Bordeaux Cedex, France.
Quentin GauthierDepartment of Chemistry and Biochemistry, Florida International University, Miami, FL, USA.
Mirna GhemrawiDepartment of Chemistry and Biochemistry, Florida International University, Miami, FL, USA.
Christian DoutremepuichLaboratoire d'Hématologie Médico-Légale, Bordeaux Cedex, France.
Bruce McCordDepartment of Chemistry and Biochemistry, Florida International University, Miami, FL, USA.
Peter M SchneiderInstitute of Legal Medicine, Faculty of Medicine and University Clinic, University of Cologne, Cologne, Germany.
Jiri DrabekInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and the University Hospital Olomouc, Olomouc, the Czech Republic.
Niels MorlingSection of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of CopenhagenCopenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human age estimation from trace samples may give important leads early in a police investigation by contributing to the description of the perpetrator. Several molecular biomarkers are available for the estimation of chronological age, and currently, DNA methylation patterns are the most promising. In this study, a QIAGEN age protocol for age estimation was tested by five forensic genetic laboratories. The assay comprised bisulfite treatment of the extracted DNA, amplification of five CpG loci (in the genes of Key points: Age determination as an intelligence tool during investigations can be a powerful tool in forensic genetics.In this study, five laboratories ran 49 samples and obtained a mean absolute deviation of 3.62 years.Five markers were analyzed on a PyroMark Q48 platform.

Indexed as

age estimationDNA methylationforensic geneticspyrosequencingtrace sample

Identifiers

PMID38567377
PMCPMC10986743

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.