ArticleFrontiers in nutrition2024
The protective role of oily fish intake against type 2 diabetes: insights from a genetic correlation and Mendelian randomization study.
Article in Frontiers in nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 4 citations in OpenAlex.
- Causal relationships between metabolic syndrome, plasma metabolites, and female reproductive diseases: insights from a two-step mendelian randomization approach.Nutrition & metabolism · 2025Article
- Bioactive Compounds in Seafood: Implications for Health and Nutrition.Food science & nutrition · 2025Review
- Causal associations of gut microbiota and pulmonary tuberculosis: a two-sample Mendelian randomization study.Frontiers in microbiology · 2024Article
- Dietary patterns related to triglyceride glucose index and risk of type 2 diabetes: a large-scale cohort study.Frontiers in nutrition · 2024Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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Abstract
Background and aims: Previous research has underscored the association between oily fish intake and type 2 diabetes (T2DM), yet the causality remains elusive. Methods: A bidirectional univariable Mendelian Randomization (MR) analysis was employed to evaluate the causal effects of oily fish and non-oily fish intake on T2DM. Replication analysis and meta-analysis were conducted to ensure robust results. Multivariable MR analysis was utilized to assess confounders, and further mediation MR analysis discerned mediating effects. Linkage Disequilibrium Score (LDSC) analysis was undertaken to compute genetic correlations. Inverse variance weighted (IVW) was the primary method, complemented by a series of sensitivity analyses. Results: The LDSC analysis unveiled a significant genetic correlation between oily fish intake and T2DM (Genetic correlation: -0.102, Conclusion: To encapsulate, there's an inverse association between oily fish intake and T2DM risk, suggesting potential benefits of oily fish intake in T2DM prevention.
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