Evidence map›Paper›PMID 38567194›Full record

ArticleOpen forum infectious diseases2024

Concurrent Administration of COVID-19 and Influenza Vaccines Enhances Spike-Specific Antibody Responses.

Susanna E Barouch, Taras M Chicz, Ross Blanc, Domenic R Barbati, Lily J Parker, Xin Tong, Wenjun Li, Ryan P McNamara

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Immunogenicity and Safety of the COVID-19 Messenger RNA Vaccine Coadministered With Influenza and 23-valent Pneumococcal Polysaccharide Vaccines.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
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  6. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Susanna E BarouchRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.
Taras M ChiczRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.
Ross BlancRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.
Domenic R BarbatiRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.
Lily J ParkerRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.
Xin TongRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.
Wenjun LiDepartment of Public Health, Center for Health Statistics and Biostatistics, University of Massachusetts at Lowell. Lowell, Massachusetts, USA.ORCID https://orcid.org/0000-0001-5335-7386
Ryan P McNamaraRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.ORCID https://orcid.org/0000-0002-8866-3532
Ragon Institute of MGH, MIT and Harvard · USUniversity of Massachusetts Lowell · US

Funding

COVID Supplement - COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES,75N93019C00052 · NIAID · UNIVERSITY OF GEORGIA · PI ROSS, TED · 2019 to 2025
$74.6M
Technology and Computational CoreP01AI165072 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI WESEMANN, DUANE R. · 2021 to 2023
$19.6M
The Development and Evaluation of Pan-Coronavirus VaccinesP01AI168347 · NIAID · WASHINGTON UNIVERSITY · PI Michael S Diamond · 2022 to 2026
$15.9M
Immunologic Signatures of SARS-CoV-2 Vaccination and DiseaseU01CA260476 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BAROUCH, DAN H. · 2020 to 2024
$3.7M
NCI NIH HHS U01 CA260476NIAID NIH HHS 75N93019C00052NIAID NIH HHS P01 AI165072NIAID NIH HHS P01 AI168347
6 · The paper itself

Abstract

Background: The bivalent COVID-19 mRNA boosters became available in fall 2022 and were recommended alongside the seasonal influenza vaccine. However, the immunogenicity of concurrent vs separate administration of these vaccines remains unclear. Methods: Here, we analyzed antibody responses in health care workers who received the bivalent COVID-19 booster and the influenza vaccine on the same day or on different days through systems serology. Antibody-binding and functional responses were characterized at peak responses and after 6 months following vaccination. Results: IgG1 and neutralization responses to SARS-CoV-2 XBB.1.5 were higher at peak and after 6 months following concurrent administration as compared with separate administration of the COVID-19 and influenza vaccines. While similar results were not observed for influenza responses, no interference was noted with concurrent administration. Conclusions: These data suggest that concurrent administration of these vaccines may yield higher and more durable SARS-CoV-2 neutralizing antibody responses while maintaining responses against influenza.

Indexed as

bivalentCOVID-19influenzavaccineXBB.1.5

Identifiers

PMID38567194
PMCPMC10986856
OpenAlexW4392745185

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.