ArticleFrontiers in cardiovascular medicine2024
TAVR-in-TAVR with a balloon-expandable valve for paravalvular leak.
Article in Frontiers in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Redo Transcatheter Aortic Valve Replacement: Device Selection and Risks.European cardiology · 2026Review
- Paravalvular Leak After Transcatheter Aortic Valve Replacement (TAVR): A Literature Review.Journal of clinical medicine · 2025Review
- Successful Surgical Therapy of a Chronically Infected Thoracic Fistula After Repeated Cardiovascular High-Risk Procedures.Clinical case reports · 2025Article
- Redo-Transcatheter Aortic Valve Replacement With a 26 mm Sapien Valve in a 26 mm Evolut Valve to Correct Significant Paravalvular Leak via Transcarotid Access.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025Article
- What is new in cardiac anesthesia in 2024?Journal of anesthesia and translational medicine · 2025Review
- Risk factors and predictive model for moderate to severe perivalvular leakage following transcatheter aortic valve replacement.American journal of translational research · 2024Article
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Paravalvular leak (PVL) is a severe complication of transcatheter aortic valve replacement (TAVR) that can lead to poor outcomes. TAVR-in-TAVR is a promising treatment for PVL; however, reports on its safety or efficacy are limited. In this study, we aimed to investigate the clinical outcomes of TAVR-in-TAVR using balloon-expandable prostheses for PVLs after TAVR. Methods: We retrospectively analyzed data from patients who underwent TAVR-in-TAVR using balloon-expandable Sapien prostheses for PVL after an initial TAVR at our institution. The procedural success, in-hospital complications, all-cause mortality, and echocardiographic data for up to 2 years post-surgery were evaluated. Results: In total, 31 patients with a mean age of 81.1 ± 7.9 years and mean Society of Thoracic Surgeons score of 8.8 ± 5.4% were identified. The procedural success rate of TAVR-in-TAVR was 96.8% (30/31). No in-hospital deaths, cardiac tamponade, or conversion to sternotomy occurred. Re-intervention was performed in only one patient (3.2%) during hospitalization. The all-cause mortality rates at 30 days and 2 years were 0% and 16.1%, respectively. A significant reduction in the PVL rate was observed at 30 days compared with that at baseline ( Discussion: Our findings suggest that TAVR-in-TAVR using balloon-expandable prostheses is safe and effective for PVL after TAVR with low complication rates and acceptable long-term outcomes. Further studies with larger sample sizes are needed to confirm our findings.
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