Evidence map›Paper›PMID 38566610›Full record

ArticleThe Journal of infectious diseases2024

High Frequency of Prior Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Sensitive Nucleocapsid Assays.

Joseph P Nkolola, Jinyan Liu, Ai-Ris Y Collier, Catherine Jacob-Dolan, Yasmeen Senussi, Ella Borberg, Zoe Swank, David R Walt, Dan H Barouch

Open access · hybridAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Protracted SARS-CoV-2 Infection in B-cell Depleted Patients: Immunologic and Viral Characteristics and Response to Dual and Extended Antiviral Therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Joseph P NkololaBeth Israel Deaconess Medical Center, Center for Virology and Vaccine Research, Boston, Massachusetts.
Jinyan LiuBeth Israel Deaconess Medical Center, Center for Virology and Vaccine Research, Boston, Massachusetts.
Ai-Ris Y CollierBeth Israel Deaconess Medical Center, Center for Virology and Vaccine Research, Boston, Massachusetts.
Catherine Jacob-DolanBeth Israel Deaconess Medical Center, Center for Virology and Vaccine Research, Boston, Massachusetts.
Yasmeen SenussiDepartment of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
Ella BorbergDepartment of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
Zoe SwankDepartment of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
David R WaltDepartment of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
Dan H BarouchBeth Israel Deaconess Medical Center, Center for Virology and Vaccine Research, Boston, Massachusetts.ORCID 0000-0001-5127-4659
Beth Israel Deaconess Medical Center · USBrigham and Women's Hospital · US

Funding

Immunologic Signatures of SARS-CoV-2 Vaccination and DiseaseU01CA260476 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BAROUCH, DAN H. · 2020 to 2024
$3.7M
Defining the optimal type and timing of COVID-19 vaccine in pregnancyR21AI169309 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI COLLIER, AI-RIS YONEKURA · 2022 to 2023
$475k
Massachusetts Consortium for Pathogen ReadinessNCI NIH HHS U01 CA260476NIAID NIH HHS R21 AI169309NIH HHS CA260476
6 · The paper itself

Abstract

Prior infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is typically measured by nucleocapsid serology assays. In this study, we show that the Simoa serology assay and T-cell intracellular cytokine staining assay are more sensitive than the clinical Elecsys assay for detection of nucleocapsid-specific immune responses. These data suggest that the prevalence of prior SARS-CoV-2 infection in the population may be higher than currently appreciated.

Indexed as

COVID-19SARS-CoV-2AdultAgedAntibodies, ViralCoronavirus Nucleocapsid ProteinsCOVID-19 Serological TestingCytokinesFemaleHumansMaleMiddle AgedNucleocapsidSensitivity and SpecificityT-LymphocytesAntibodies, ViralCoronavirus Nucleocapsid ProteinsCytokinesimmunityinfectionnucleocapsidSARS-CoV-2serology

Identifiers

PMID38566610
PMCPMC11420766
OpenAlexW4393856164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.