ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2024
Design of the Intervention to Reduce Early Peanut Allergy in Children (iREACH): A practice-based clinical trial.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04604431 (Intervention to Reduce Early), which is not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intervention to Reduce Early (Peanut) Allergy in Children
Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Assessing pediatric clinician adherence to the guidelines for prevention of peanut allergy: a natural language processing study.BMC medical informatics and decision making · 2025Trial
- Pediatric Clinician Adherence to Peanut Allergy Prevention Guidelines: A Randomized Trial.Pediatrics · 2025Trial
- Implementation of early peanut introduction among providers in a southern US state.The journal of allergy and clinical immunology. Global · 2026Article
- Review
- Disparities in Caregiver-Reported Knowledge, Attitudes, Behaviors, and Clinical Guidance Regarding Primary Prevention of Peanut Allergy.Academic pediatricsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIntroducing peanut products early can prevent peanut allergy (PA). The "Addendum guidelines for the prevention of PA in the United States" (PPA guidelines) recommend early introduction of peanut products to low and moderate risk infants and evaluation prior to starting peanut products for infants at high risk for PA (those with severe eczema and/or egg allergy). Rapid adoption of guidelines could aid in lowering the prevalence of PA. The Intervention to Reduce Early (Peanut) Allergy in Children (iREACH) trial was designed to promote PPA guideline adherence by pediatric clinicians.
methodsA two-arm, cluster-randomized, controlled clinical trial was designed to measure the effectiveness of an intervention that included clinician education and accompanying clinical decision support tools integrated in electronic health records (EHR) versus standard care. Randomization was at the practice level (n = 30). Primary aims evaluated over an 18-month trial period assess adherence to the PPA guidelines using EHR documentation at 4- and 6-month well-child care visits aided by natural language processing. A secondary aim will evaluate the effectiveness in decreasing the incidence of PA by age 2.5 years using EHR documentation and caregiver surveys. The unit of observation for evaluations are individual children with clustering at the practice level.
conclusionApplication of this intervention has the potential to inform the development of strategies to speed implementation of PPA guidelines.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.