ArticlePediatric transplantation2024
Semilunar valve growth and function 10 years after infant heart transplantation: Predicting long-term outcomes of partial heart transplants.
Article in Pediatric transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Leaflet Length is a Reliable Measure of Aortic Valve Growth.Pediatric cardiology · 2026Article
- Semilunar Valves in Pediatric Orthotopic Heart Transplants Grow at a Slower Rate than Controls.Pediatric cardiology · 2026Article
- Valve function during graft rejection and before graft failure in pediatric heart transplant recipients.JTCVS open · 2026Article
- Fate of Discarded Hearts Donated After Circulatory Death: Is There an Opportunity for Novel Use?Annals of thoracic surgery short reports · 2025Article
- Indications and Practical Considerations for Partial Heart Transplantation.The Annals of thoracic surgery · 2025Review
- Suitability of Infant Heart Transplant Recipients to Serve as Domino Partial Heart Transplant Donors.Pediatric transplantation · 2025Article
- Partial Heart Transplant Growth and Hemodynamic Function in Piglets.JACC. Basic to translational science · 2024Article
- Partial Heart Transplantation.Circulation · 2024Article
- Organizational challenges for partial heart transplantation.Future cardiology · 2024Review
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Authors and funding
6 authors at 3 institutions in 1 country.
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Abstract
introductionPartial heart transplants are a new type of pediatric transplant that replace defective heart valves with the parts of matched donor hearts containing the necessary valves. Short-term outcomes of partial heart transplants are excellent, but long-term outcomes are unknown. In order to predict the long-term outcomes of partial heart transplants, we evaluated long-term growth and function of semilunar heart valves transplanted in infancy as part of a heart transplant.
methodsAll children who underwent infant heart transplantation at a single center from 1997 to 2014 were included in this study. Children in whom echocardiograms after heart transplantation and after 10 years were not available for review were excluded. The echocardiograms were reviewed by two authors to analyze semilunar valve annulus diameters, Z-scores, peak valve gradients, and valve regurgitation. Statistical difference was determined using two-tailed, paired sample t-tests with Bonferroni correction for multiple comparisons.
resultsData from 15 patients were analyzed. The aortic valve annulus averaged 1.3 cm (range 0.7-1.8 cm) immediately after transplantation and grew to an average of 1.7 cm (range 1.4-2.3 cm) after 10 years (p < .001). After 10 years, the aortic valve peak gradient avereraged 5.1 mmHg (range 2.1-15.5 mmHg) and none of the valves had more than trivial regurgitation. The pulmonary valve annulus averaged 1.5 cm (range 1.1-2.5 cm) immediately after transplantation and grew to an average of 2.1 cm (range 1.0-2.9 cm) after 10 years (p < .001). After 10 years, the pulmonary valve peak gradient averaged 4.3 mmHg (range 1.1-13.8 mmHg), and 7% of valves had moderate regurgitation. DISCUSSION: Semilunar heart valves transplanted in infancy as part of a heart transplant demonstrate statistically significant growth and excellent function after 10 years. This predicts excellent long-term outcomes of partial heart transplants.
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