Evidence map›Paper›PMID 38566213›Full record

ArticleJournal of nanobiotechnology2024

Tea polyphenol-derived nanomedicine for targeted photothermal thrombolysis and inflammation suppression.

Hui Wang, Cui Tang, Yuxia Xiang, Chan Zou, Jianming Hu, Guoping Yang, Wenhu Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hui WangCenter of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Cui TangXiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013, China.
Yuxia XiangCenter of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Chan ZouCenter of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Jianming HuFirst Department of Pathology, Affiliated Hospital, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, 832002, China.
Guoping YangCenter of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China. ygp9880@126.com.
Wenhu ZhouXiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013, China. zhouwenhuyaoji@163.com.
Central South University · CNShihezi University · CN

Funding

Major project of Hunan Provincial Science& Technology department 2020SK2010National Major New Drug Creation Project of China 2020ZX09201-010Natural Science Foundation of Hunan province in China 2021JJ20084the Non-profit Central Research Institute Fund of Chines Academy of Medical Sciences 2020-PT330-003the Science and Technology Innovation Program of Hunan Province 2021RC3020
6 · The paper itself

Abstract

Thrombotic diseases impose a significant global health burden, and conventional drug-based thrombolytic therapies are encumbered by the risk of bleeding complications. In this study, we introduce a novel drug-free nanomedicine founded on tea polyphenols nanoparticles (TPNs), which exhibits multifaceted capabilities for localized photothermal thrombolysis. TPNs were synthesized through a one-pot process under mild conditions, deriving from the monomeric epigallocatechin-3-gallate (EGCG). Within this process, indocyanine green (ICG) was effectively encapsulated, exploiting multiple intermolecular interactions between EGCG and ICG. While both TPNs and ICG inherently possessed photothermal potential, their synergy significantly enhanced photothermal conversion and stability. Furthermore, the nanomedicine was functionalized with cRGD for targeted delivery to activated platelets within thrombus sites, eliciting robust thrombolysis upon laser irradiation across diverse thrombus types. Importantly, the nanomedicine's potent free radical scavenging abilities concurrently mitigated vascular inflammation, thus diminishing the risk of disease recurrence. In summary, this highly biocompatible multifunctional nanomaterial holds promise as a comprehensive approach that combines thrombolysis with anti-inflammatory actions, offering precision in thrombosis treatment.

Indexed as

NanomedicineThrombosisHumansIndocyanine GreenInflammationPolyphenolsTeaThrombolytic TherapyIndocyanine GreenPolyphenolsTeacRGD peptideFree radical scavengingPhotothermal therapyPlatelet activationTargeted deliveryThrombotic diseases

Identifiers

PMID38566213
PMCPMC10988797
OpenAlexW4393900160

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.