ArticleCell communication and signaling : CCS2024
JAK/STAT mediated insulin resistance in muscles is essential for effective immune response.
Article in Cell communication and signaling : CCS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- mTOR signaling regulates demand-adapted hematopoiesis and metabolic reprogramming required for an effective cellular immune response in Drosophila melanogaster larvae.PLoS genetics · 2026Article
- Metabolic Regulation in the Maintenance ofInternational journal of molecular sciences · 2026Review
- Tachykinin-related peptide signalling is important for the immune response of the mealworm beetleFrontiers in immunology · 2026Article
- Article
- Muscling in on immunity: the role of muscle in the insect immune response, demonstrating the value of a whole organism perspective.Frontiers in immunology · 2026Review
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- Imidacloprid contributes to bladder cancer progression: preliminary evidence based on network toxicology, machine learning and molecular docking.BMC pharmacology & toxicology · 2025Article
- Article
- Association of visceral fat metabolism score with risk of rheumatoid arthritis in US adults.Frontiers in nutrition · 2025Article
- Editorial: Community series in recent advances inFrontiers in immunology · 2024Article
- How to eliminate pathogen without killing oneself? Immunometabolism of encapsulation and melanization inFrontiers in immunology · 2023Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThe metabolically demanding nature of immune response requires nutrients to be preferentially directed towards the immune system at the expense of peripheral tissues. We study the mechanisms by which this metabolic reprograming occurs using the parasitoid infection of Drosophila larvae. To overcome such an immune challenge hemocytes differentiate into lamellocytes, which encapsulate and melanize the parasitoid egg. Hemocytes acquire the energy for this process by expressing JAK/STAT ligands upd2 and upd3, which activates JAK/STAT signaling in muscles and redirects carbohydrates away from muscles in favor of immune cells.
methodsImmune response of Drosophila larvae was induced by parasitoid wasp infestation. Carbohydrate levels, larval locomotion and gene expression of key proteins were compared between control and infected animals. Efficacy of lamellocyte production and resistance to wasp infection was observed for RNAi and mutant animals.
resultsAbsence of upd/JAK/STAT signaling leads to an impaired immune response and increased mortality. We demonstrate how JAK/STAT signaling in muscles leads to suppression of insulin signaling through activation of ImpL2, the inhibitor of Drosophila insulin like peptides.
conclusionsOur findings reveal cross-talk between immune cells and muscles mediates a metabolic shift, redirecting carbohydrates towards immune cells. We emphasize the crucial function of muscles during immune response and show the benefits of insulin resistance as an adaptive mechanism that is necessary for survival.
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