Evidence map›Paper›PMID 38566179›Full record

Observational studyCritical care (London, England)2024

Facial appearance associates with longitudinal multi-organ failure: an ICU cohort study.

Eline G M Cox, Bas C T van Bussel, Nerea Campillo Llamazares, Jan-Willem E M Sels, Marisa Onrust, Iwan C C van der Horst, Jacqueline Koeze, SICS Study Group

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Critical care (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Eline G M CoxDepartment of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. e.g.m.cox@umcg.nl.
Bas C T van BusselDepartment of Intensive Care Medicine, Maastricht University Medical Center+, University Maastricht, Maastricht, the Netherlands.
Nerea Campillo LlamazaresDepartment of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jan-Willem E M SelsDepartment of Intensive Care Medicine, Maastricht University Medical Center+, University Maastricht, Maastricht, the Netherlands.
Marisa OnrustDepartment of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Iwan C C van der HorstDepartment of Intensive Care Medicine, Maastricht University Medical Center+, University Maastricht, Maastricht, the Netherlands.
Jacqueline KoezeDepartment of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
SICS Study Group
University Medical Center Groningen · NLMaastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFacial appearance, whether consciously or subconsciously assessed, may affect clinical assessment and treatment strategies in the Intensive Care Unit (ICU). Nevertheless, the association between objective clinical measurement of facial appearance and multi-organ failure is currently unknown. The objective of this study was to examine whether facial appearance at admission is associated with longitudinal evaluation of multi-organ failure.

methodsThis was a sub-study of the Simple Intensive Care Studies-II, a prospective observational cohort study. All adult patients acutely admitted to the ICU between March 26, 2019, and July 10, 2019, were included. Facial appearance was assessed within three hours of ICU admission using predefined pictograms. The SOFA score was serially measured each day for the first seven days after ICU admission. The association between the extent of eye-opening and facial skin colour with longitudinal Sequential Organ Failure Assessment (SOFA) scores was investigated using generalized estimation equations.

resultsSOFA scores were measured in 228 patients. Facial appearance scored by the extent of eye-opening was associated with a higher SOFA score at admission and follow-up (unadjusted 0.7 points per step (95%CI 0.5 to 0.9)). There was no association between facial skin colour and a worse SOFA score over time. However, patients with half-open or closed eyes along with flushed skin had a lower SOFA score than patients with a pale or normal facial skin colour (P-interaction < 0.1).

conclusionsThe scoring of patients' facial cues, primarily the extent of eye-opening and facial colour, provided valuable insights into the disease state and progression of the disease of critically ill patients. The utilization of advanced monitoring techniques that incorporate facial appearance holds promise for enhancing future intensive care support.

Indexed as

Intensive Care UnitsMultiple Organ FailureAdultCohort StudiesHumansOrgan Dysfunction ScoresPrognosisProspective StudiesRetrospective StudiesCritical careFacial appearanceFacial monitoringGut feelingMulti-organ failure

Identifiers

PMID38566179
PMCPMC10988949
OpenAlexW4393398406

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.