ArticleCardiovascular diabetology2024
The effect of hyperlipidemia and body fat distribution on subclinical left ventricular function in obesity: a cardiovascular magnetic resonance study.
Article in Cardiovascular diabetology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 8 citations in OpenAlex.
- Identifying high-risk and actionable profiles for prevention in hypertensive patients with concurrent dyslipidemia: a population-based retrospective study.BMC cardiovascular disorders · 2026Observational
- Myocardial interstitial fibrosis and subclinical left ventricular systolic dysfunction in type 2 diabetes mellitus patients with obesity: a 3.0 T MRI study.Cardiovascular diabetology · 2025Article
- Sex-Specific Association Between Serum VitaminD and Health Status Among Chinese Obesity People: A Cross-Sectional Study.Obesity surgery · 2025Article
- Association between elevated serum total cholesterol and increased risk of post-induction hypotension in elderly patients undergoing non-cardiac surgery: a retrospective cohort study.Lipids in health and disease · 2025Article
- Establishing a Prediction Model for Weight Loss Outcomes After LSG in Chinese Obese Patients with BMI ≥ 32.5 Kg/mDiabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Sex-Specific Associations Between Anthropometric Indices and Left Ventricular Hypertrophy in Middle-Aged and Elderly Individuals with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Diastolic dysfunction in adults with uncomplicated obesity evaluated with left atrial and left ventricular tissue tracking and ventricular volume-time curve: a prospective cardiac magnetic resonance study.Quantitative imaging in medicine and surgery · 2024Article
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9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundObesity is often associated with multiple comorbidities. However, whether obese subjects with hyperlipidemia in the absence of other complications have worse cardiac indices than metabolically healthy obese subjects is unclear. Therefore, we aimed to determine the effect of hyperlipidemia on subclinical left ventricular (LV) function in obesity and to evaluate the association of cardiac parameters with body fat distribution. MATERIALS AND
methodsNinety-two adults were recruited and divided into 3 groups: obesity with hyperlipidemia (n = 24, 14 males), obesity without hyperlipidemia (n = 25, 13 males), and c ntrols (n = 43, 25 males). LV strain parameters (peak strain (PS), peak diastolic strain rate (PDSR), peak systolic strain rate) derived from cardiovascular magnetic resonance tissue tracking were measured and compared. Dual-energy X-ray absorptiometer was used to measure body fat distribution. Correlations of hyperlipidemia and body fat distribution with LV strain were assessed by multivariable linear regression.
resultsObese individuals with preserved LV ejection fraction showed lower global LV longitudinal, circumferential, and radial PS and longitudinal and circumferential PDSR than controls (all P < 0.05). Among obese patients, those with hyperlipidemia had lower longitudinal PS and PDSR and circumferential PDSR than those without hyperlipidemia (- 12.8 ± 2.9% vs. - 14.2 ± 2.7%, 0.8 ± 0.1 s
conclusionHyperlipidemia is independently associated with subclinical LV diastolic dysfunction in obesity. Central fat distribution (android and visceral fat) has a negative association, while peripheral fat distribution (gynoid fat) has a positive association on subclinical LV function. These results suggest that appropriate management of hyperlipidemia may be beneficial for obese patients, and that the differentiation of fat distribution in different regions may facilitate the precise management of obese patients. Clinical trials registration Effect of lifestyle intervention on metabolism of obese patients based on smart phone software (ChiCTR1900026476).
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