Evidence map›Paper›PMID 38566082›Full record

ArticleCardiovascular diabetology2024

The neutrophil-to-lymphocyte ratio is associated with all-cause and cardiovascular mortality among individuals with hypertension.

Xuexue Zhang, Rui Wei, Xujie Wang, Wantong Zhang, Mengxuan Li, Tian Ni, Weiliang Weng, Qiuyan Li

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Article in Cardiovascular diabetology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
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101citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Systemic inflammatory profiles associated with early EEG abnormalities following ischemic stroke: a cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Observational
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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Xuexue Zhang *Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Rui Wei *Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Xujie Wang *Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Wantong ZhangXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Mengxuan LiXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Tian NiXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Weiliang Weng *Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. ww6488@126.com.
Qiuyan Li *Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. liqiuyan0928@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdentifying reliable prognostic markers is crucial for the effective management of hypertension. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potential inflammatory marker linked to cardiovascular outcomes. This study aims to investigate the association of NLR with all-cause and cardiovascular mortality among patients with hypertension.

methodsThis study analyzed data from 3067 hypertensive adults in the National Health and Nutritional Examination Surveys (NHANES) from 2009 to 2014. Mortality details were obtained from the National Death Index (NDI). Restricted cubic spline (RCS) was deployed to visualize the association of the NLR with mortality risk. Weighted Cox proportional hazards models were employed to assess the independent association of NLR with mortality risk. Time-dependent receiver operating characteristic curve (ROC) analysis was conducted to access the predictive ability of NLR for survival. Mediation analysis was used to explore the indirect impact of NLR on mortality mediated through eGFR.

resultsOver a median 92.0-months follow-up, 538 deaths occurred, including 114 cardiovascular deaths. RCS analysis revealed a positive association between NLR and both all-cause and cardiovascular mortality. Participants were stratified into higher (> 3.5) and lower (≤ 3.5) NLR groups. Weighted Cox proportional hazards models demonstrated that individuals with higher NLR had a significantly increased risk of all-cause (HR 1.96, 95% confidence interval (CI) 1.52-2.52, p < 0.0001) and cardiovascular mortality (HR 2.33, 95% CI 1.54-3.51, p < 0.0001). Stratified and interaction analysis confirmed the stability of the core results. Notably, eGFR partially mediated the association between NLR and both all-cause and cardiovascular mortality by a 5.4% and 4.7% proportion, respectively. Additionally, the areas under the curve (AUC) of the 3-, 5- and 10- year survival was 0.68, 0.65 and 0.64 for all-cause mortality and 0.68, 0.70 and 0.69 for cardiovascular mortality, respectively.

conclusionElevated NLR independently confers an increased risk for both all-cause and cardiovascular mortality in individuals with hypertension.

Indexed as

Cardiovascular SystemHypertensionAdultHumansLymphocytesNeutrophilsNutrition SurveysPrognosisRetrospective StudiesAll-cause mortalityCardiovascular mortalityHypertensionNeutrophil lymphocyte ratio

Identifiers

PMID38566082
PMCPMC10985955

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.