Evidence map›Paper›PMID 38565970›Full record

ReviewNature immunology2024

Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders.

Eunha Kim, Jun R Huh, Gloria B Choi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
32.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

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  9. Microglia as critical mediators linking perinatal immune stress to mental health trajectories.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Eunha KimBK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea. eunha_kim@korea.ac.kr.ORCID http://orcid.org/0000-0001-7041-1727
Jun R HuhDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1540-6244
Gloria B ChoiThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. gbchoi@mit.edu.ORCID http://orcid.org/0000-0003-4050-8338
Harvard University · USKorea University · KRMcGovern Institute for Brain Research · US

Funding

Pregnancy influences maternal immune cell function and fetal brain developmentR01MH119459 · NIMH · HARVARD MEDICAL SCHOOL · PI Jun R. Huh · 2019 to 2026
$3.9M
Korea University (KU) K2225821Ministry of Trade, Industry and Energy (Ministry of Trade, Industry and Energy, Korea) 20023378National Research Foundation of Korea (NRF) RS-2023-00209464NIMH NIH HHS R01 MH119459U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH115307U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH119459
6 · The paper itself

Abstract

The intricate relationship between immune dysregulation and neurodevelopmental disorders (NDDs) has been observed across the stages of both prenatal and postnatal development. In this Review, we provide a comprehensive overview of various maternal immune conditions, ranging from infections to chronic inflammatory conditions, that impact the neurodevelopment of the fetus during pregnancy. Furthermore, we examine the presence of immunological phenotypes, such as immune-related markers and coexisting immunological disorders, in individuals with NDDs. By delving into these findings, we shed light on the potential underlying mechanisms responsible for the high occurrence of immune dysregulation alongside NDDs. We also discuss current mouse models of NDDs and their contributions to our understanding of the immune mechanisms underlying these diseases. Additionally, we discuss how neuroimmune interactions contribute to shaping the manifestation of neurological phenotypes in individuals with NDDs while also exploring potential avenues for mitigating these effects.

Indexed as

Neurodevelopmental DisordersNeuroimmunomodulationAnimalsDisease Models, AnimalFemaleMicePregnancy

Identifiers

PMID38565970
OpenAlexW4393409270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.