Evidence map›Paper›PMID 38565959›Full record

SynthesisNature protocols2024

Packaging and containerization of computational methods.

Mohammed Alser, Brendan Lawlor, Richard J Abdill, Sharon Waymost, Ram Ayyala, Neha Rajkumar, Nathan LaPierre, Jaqueline Brito, André M Ribeiro-Dos-Santos, Nour Almadhoun and 10 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Nature protocols, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Autonomous Self-Evolving Research on Biomedical Data: The DREAM Paradigm.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Mohammed AlserDepartment of Information Technology and Electrical Engineering, ETH Zürich, Zurich, Switzerland.ORCID 0000-0002-6117-3701
Brendan LawlorDepartment of Computer Science, Munster Technological University, Cork, Ireland.ORCID 0000-0002-2250-0669
Richard J AbdillSection of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-9565-5832
Sharon WaymostDepartment of Computer Science, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-1176-5386
Ram AyyalaDepartment of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA.
Neha RajkumarDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Nathan LaPierreDepartment of Computer Science, University of California, Los Angeles, Los Angeles, CA, USA.
Jaqueline BritoTitus Family Department of Clinical Pharmacy, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, USA.
André M Ribeiro-Dos-SantosInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.
Nour AlmadhounDepartment of Information Technology and Electrical Engineering, ETH Zürich, Zurich, Switzerland.
Varuni SarwalDepartment of Computer Science, University of California, Los Angeles, Los Angeles, CA, USA.
Can FirtinaDepartment of Information Technology and Electrical Engineering, ETH Zürich, Zurich, Switzerland.ORCID 0000-0002-6548-7863
Tomasz OsinskiCenter for Advanced Research Computing, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-9933-346X
Eleazar EskinDepartment of Computer Science, University of California, Los Angeles, Los Angeles, CA, USA.
Qiyang HuOffice of Advanced Research Computing, University of California, Los Angeles, CA, USA.
Derek StrongCenter for Advanced Research Computing, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-0347-8574
Byoung-Do B D KimCenter for Advanced Research Computing, University of Southern California, Los Angeles, CA, USA.
Malak S AbedalthagafiDepartment of Pathology & Laboratory Medicine, Emory University Hospital, Atlanta, GA, USA.ORCID 0000-0003-1786-3366
Onur MutluDepartment of Information Technology and Electrical Engineering, ETH Zürich, Zurich, Switzerland.
Serghei MangulDepartment of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA. serghei.mangul@gmail.com.ORCID 0000-0003-4770-3443

Funding

Developing robust and scalable genomics tools and databases to analyze immune receptor repertoires across diverse populationsR01AI173172 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALACHKAR, HOUDA · 2023 to 2025
$2.5M
NIAID NIH HHS R01 AI173172
6 · The paper itself

Abstract

Methods for analyzing the full complement of a biomolecule type, e.g., proteomics or metabolomics, generate large amounts of complex data. The software tools used to analyze omics data have reshaped the landscape of modern biology and become an essential component of biomedical research. These tools are themselves quite complex and often require the installation of other supporting software, libraries and/or databases. A researcher may also be using multiple different tools that require different versions of the same supporting materials. The increasing dependence of biomedical scientists on these powerful tools creates a need for easier installation and greater usability. Packaging and containerization are different approaches to satisfy this need by delivering omics tools already wrapped in additional software that makes the tools easier to install and use. In this systematic review, we describe and compare the features of prominent packaging and containerization platforms. We outline the challenges, advantages and limitations of each approach and some of the most widely used platforms from the perspectives of users, software developers and system administrators. We also propose principles to make the distribution of omics software more sustainable and robust to increase the reproducibility of biomedical and life science research.

Indexed as

Computational BiologySoftwareHumansProteomics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.